Boc-(4S)-4-azido-D-proline dicyclohexylamine salt - CAS 132622-77-6

Boc-(4S)-4-azido-D-proline dicyclohexylamine salt - CAS 132622-77-6 Catalog number: BADC-01973

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Category
ADCs Linker
Product Name
Boc-(4S)-4-azido-D-proline dicyclohexylamine salt
CAS
132622-77-6
Catalog Number
BADC-01973
Molecular Formula
C10H16N4O4·C12H23N
Molecular Weight
437.60

Ordering Information

Catalog Number Size Price Quantity
BADC-01973 -- $--
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Synonyms
Boc-D-Pro(4-N3) DCHA; (2R,4S); Boc-(2R,4S)-4-azidoproline dicyclohexylamine salt
IUPAC Name
(2R,4S)-4-azido-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Canonical SMILES
CC(C)(C)OC(=O)N1CC(CC1C(=O)O)N=[N+]=[N-]
InChI
InChI=1S/C10H16N4O4/c1-10(2,3)18-9(17)14-5-6(12-13-11)4-7(14)8(15)16/h6-7H,4-5H2,1-3H3,(H,15,16)/t6-,7+/m0/s1
InChIKey
JZEOWBJXFSZTJU-NKWVEPMBSA-N
Melting Point
144-150°C
Appearance
White crystalline powder
Purity
≥ 99% (Assay by titration)
Storage
Store at 2-8 °C

Boc-(4S)-4-azido-D-proline dicyclohexylamine salt, a specialized chemical essential for advanced bioscience applications, finds diverse uses in various fields. Below are four key applications highlighted with high perplexity and burstiness:

Peptide Synthesis: Within the realm of peptide synthesis, Boc-(4S)-4-azido-D-proline plays a pivotal role in crafting peptides by incorporating azido groups into their structures. These azido groups are crucial for click chemistry reactions, facilitating the creation of intricate peptide architectures. This capability empowers researchers to design and fabricate peptides tailored with specific functionalities for therapeutic and diagnostic endeavors.

Drug Development: Delving into pharmaceutical research, Boc-(4S)-4-azido-D-proline emerges as a key component in the exploration of drug candidates’ pharmacokinetics and pharmacodynamics. The presence of the azido group enables seamless bioconjugation and labeling, enabling meticulous tracking and analysis of the interactions between drug candidates and biological targets. This in-depth understanding aids in refining drug design, elevating efficacy, and enhancing safety profiles.

Protein Engineering: Moving into the realm of protein engineering, Boc-(4S)-4-azido-D-proline proves to be a valuable asset for probing protein structures and functions. By integrating the azido group into proteins, researchers can conduct site-specific modifications like attaching fluorescent probes or other chemical entities. This technique facilitates the visualization and comprehension of protein folding dynamics and interactions, enriching our understanding of protein behavior.

Bioconjugation Techniques: In the domain of biotechnology, Boc-(4S)-4-azido-D-proline finds utility in crafting innovative bioconjugates. Leveraging click chemistry, it serves as a linchpin for establishing robust bonds between biomolecules, such as linking enzymes to antibodies or other targeting agents. This method enhances the specificity and functionality of bioconjugates, paving the way for transformative applications in diagnostics, therapeutics, and bioassays.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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