Name: Bis-PEG9-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Price

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$--

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Synonyms

4,7,10,13,16,19,22,25,28-Nonaoxahentriacontanedioic acid; HOOC-PEG9-COOH; HOOCCH2CH2O-PEG8-CH2CH2COOH; α,ω-dipropionic acid octaethylene glycol; 4,7,10,13,16,19,22,25,28-Nonaoxahentriacontane-1,31-dioic acid

IUPAC Name

3-[2-[2-[2-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Canonical SMILES

C(COCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O)C(=O)O

InChI

InChI=1S/C22H42O13/c23-21(24)1-3-27-5-7-29-9-11-31-13-15-33-17-19-35-20-18-34-16-14-32-12-10-30-8-6-28-4-2-22(25)26/h1-20H2,(H,23,24)(H,25,26)

InChIKey

MZPXCHJGEDEJHQ-UHFFFAOYSA-N

Density

1.174±0.06 g/cm3 (Predicted)

Solubility

Soluble in DMSO (10 mm)

Flash Point

201.6±25.0 °C

Index Of Refraction

1.472

Vapor Pressure

0.0±4.0 mmHg at 25°C

Appearance

Pale Yellow or Colorless Oily Matter

Shipping

Room temperature

Storage

Store at 2-8°C

Boiling Point

630.0±55.0 °C at 760 mmHg

Bis-PEG9-acid, a derivative of polyethylene glycol, is widely utilized in biomedical research and bioconjugation. Here are four key applications of Bis-PEG9-acid described with a high degree of perplexity and burstiness:

Drug Delivery Systems: Leveraging the versatility of Bis-PEG9-acid, researchers can modify drug molecules to boost their solubility, stability, and bioavailability. Through the conjugation of drugs with Bis-PEG9-acid, the pharmacokinetic properties of these medications can be enhanced, leading to more potent and efficient treatments. This methodology is particularly beneficial for drugs with low water solubility or rapid clearance rates from the body.

Protein Modification: At the forefront of therapeutic advancements, Bis-PEG9-acid plays a crucial role in protein PEGylation—a process that entails the attachment of polyethylene glycol chains to proteins. This modification elevates the stability and half-life of therapeutic proteins, thereby reducing their immunogenicity and enhancing their therapeutic efficacy. PEGylated proteins find extensive applications in combating various diseases, including cancer and chronic inflammatory conditions.

Surface Coating: Delving into the realm of biocompatibility, Bis-PEG9-acid is harnessed to engineer surfaces for medical devices and implants. By coating surfaces with Bis-PEG9-acid, researchers can curtail protein adsorption and cell adhesion, thereby mitigating the risks of immune reactions and infections. This application is pivotal in elevating the performance and safety standards of implants and other biomedical devices.

Nanotechnology: In the intricate domain of nanotechnology, Bis-PEG9-acid emerges as a cornerstone for functionalizing nanoparticles tailored for targeted drug delivery and imaging endeavors. By attaching Bis-PEG9-acid to the nanoparticle surfaces, researchers can enhance their circulation longevity and targeting precision. This cutting-edge approach bolsters the precision and efficiency of nanoparticle-based therapies and diagnostic tools, ushering in a new era of precision medicine.