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Azide-PEG5-Tos is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01105 | -- | $-- | Inquiry |
Azide-PEG5-Tos is a versatile chemical reagent with diverse applications in bioconjugation and chemical synthesis. Here are four key applications of Azide-PEG5-Tos presented with a high degree of perplexity and burstiness:
Bioconjugation: At the forefront of biomolecular attachment, Azide-PEG5-Tos is a staple reagent for linking proteins, peptides, and nucleic acids to surfaces or other molecules through click chemistry reactions. This ingenious method gives rise to functionalized nanoparticles, biosensors, and diagnostic tools, pushing the boundaries of biofunctional material engineering. The inclusion of a polyethylene glycol (PEG) spacer not only enhances solubility but also mitigates steric hindrance, streamlining the conjugation process with finesse and precision.
Drug Delivery: Unveiling new horizons in drug transportation, Azide-PEG5-Tos plays a pivotal role in modifying drugs or drug carriers with azide groups, paving the way for subsequent conjugation with targeting ligands or therapeutic agents using click chemistry tactics. This groundbreaking approach catalyzes the creation of targeted drug delivery systems that hold the promise of heightened treatment efficacy and reduced adverse effects. The biocompatible nature of the PEG spacer further optimizes the pharmacokinetics of drug carriers, propelling advancements in therapeutic interventions to unparalleled heights.
Surface Modification: Embarking on the frontier of biomaterial surfaces, Azide-PEG5-Tos emerges as a transformative agent for enhancing biocompatibility and biofunctionality. By leveraging its capabilities to functionalize surfaces of biomaterials, profound improvements are witnessed in the performance of implants and medical devices. The strategic modification of these surfaces with PEG and biologically active molecules not only curtails protein adsorption and bacterial adhesion but also fosters robust tissue integration, heralding a new era of advanced implants and medical devices endowed with superior performance and longevity.
Molecular Imaging: Enter the realm of molecular imaging, where Azide-PEG5-Tos takes center stage in the synthesis of imaging probes tailored for cutting-edge applications. Utilizing Azide-PEG5-Tos to conjugate imaging agents to specific biomolecules, molecular imaging probes can be precisely directed to target tissues or cells within the intricate biological landscape. This precision enables the visualization of dynamic biological processes and disease states through innovative techniques like fluorescence imaging and positron emission tomography (PET).
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
