Name: CHO-Ph-CONH-PEG5-azide
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

Ald-Ph-PEG5-Azide; DF-PEG5-N3; Ald-Ph-amido-C2-PEG5-azide; Ald-Ph-PEG5-N3; CHO-Ph-PEG5-azide; N3-PEG5-aldehyde; N-(17-Azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-4-formylbenzamide; Benzamide, N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-4-formyl-

IUPAC Name

N-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-4-formylbenzamide

Canonical SMILES

C1=CC(=CC=C1C=O)C(=O)NCCOCCOCCOCCOCCOCCN=[N+]=[N-]

InChI

InChI=1S/C20H30N4O7/c21-24-23-6-8-28-10-12-30-14-16-31-15-13-29-11-9-27-7-5-22-20(26)19-3-1-18(17-25)2-4-19/h1-4,17H,5-16H2,(H,22,26)

InChIKey

VEASZCUTKBUAIG-UHFFFAOYSA-N

Storage

Store at 2-8°C

CHO-Ph-CONH-PEG5-azide, a versatile building block utilized in bioconjugation and drug delivery, offers a multitude of applications. Here are four key applications:

Bioconjugation: Widely employed in bioconjugation, CHO-Ph-CONH-PEG5-azide acts as a pivotal link between biomolecules like proteins, antibodies, and peptides. Featuring an azide group, this molecule engages in click chemistry reactions with alkyne-containing molecules to forge stable triazole linkages. This process facilitates the attachment of functional labels or therapeutic agents to biomolecules, serving the dual purposes of research and therapy.

Drug Delivery: In the realm of drug delivery systems, CHO-Ph-CONH-PEG5-azide plays a crucial role as a linker molecule, connecting therapeutic agents to carrier molecules such as nanoparticles or polymers. The inclusion of a polyethylene glycol (PEG) spacer enhances solubility and biocompatibility while maintaining spatial separation between the drug and carrier. This spatial distinction can enhance the pharmacokinetics and diminish immunogenicity of the drug delivery system.

Diagnostics: Valuable in diagnostic assay development, CHO-Ph-CONH-PEG5-azide is utilized in producing imaging agents and diagnostic tools. By conjugating the azide-functionalized molecule with imaging probes or contrast agents, researchers can create targeted diagnostic tools for identifying specific biomarkers. This precision enables more accurate disease imaging and diagnosis, particularly in conditions like cancer and cardiovascular diseases.

Surface Modification: CHO-Ph-CONH-PEG5-azide finds application in surface modification, impacting various materials including nanoparticles, polymers, and biochips. Through PEGylation, this compound enhances surface properties such as hydrophilicity and reduces non-specific binding. These surface modifications play a pivotal role in the development of biosensors, fostering biocompatibility and mitigating biofouling in medical devices and analytical platforms.