Inquiry Basket
Loading......
CAS No.: 906564-59-8
Cat No.: BADC-00434
Purity: ≥98%
4.5 
5-hexynoic NHS ester is a bioorthogonal conjugation building block that provides a bioorthogonal click handle for modular click-chemistry workflows. The molecule can be used to introduce a click-reactive group onto an antibody, peptide, linker intermediate, or payload-containing component, depending on the chemistry of its second terminal functionality. Its additional reactive group is nhs/succinimidyl ester (amine-reactive) for antibody lysines/primary amines. Conjugation can be performed using spaac with dbco/bcn-functionalized partner or cuaac with terminal alkyne partner, depending the complementary handle. The sequence and orientation of the coupling steps should be selected according to the functional groups carried by the two conjugation partners.
Structure of 906564-59-8
* For research and manufacturing use only. We do not sell to patients.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
Popular Publications Citing BOC Sciences Products
5-Hexynoic NHS ester, a versatile chemical reagent extensively utilized in bioconjugation and chemical biology, offers a multitude of applications. Here are four key applications presented with high perplexity and burstiness:
Protein Labeling: A common practice involves utilizing 5-Hexynoic NHS ester to label proteins with alkyne groups, setting the stage for subsequent ""click"" chemistry reactions with azide-functionalized molecules. These labeled proteins become crucial components in diverse biochemical assays and imaging studies, providing valuable insights into cellular processes at a molecular level.
Antibody Conjugation: The reactive NHS ester group in 5-Hexynoic NHS ester engages with primary amines, making it a prime candidate for conjugating antibodies. This conjugation process yields antibody-drug conjugates tailored for targeted drug delivery or facilitates the labeling of antibodies with fluorescent dyes. These conjugates play a pivotal role in diagnostic and therapeutic applications, enhancing precision in disease detection and treatment.
Surface Functionalization: Enabling surface modification with alkyne groups, 5-Hexynoic NHS ester opens the door to bioorthogonal reactions that drive the development of biosensors and microarrays. These applications find significance in high-throughput screening and diagnostic technologies, offering a glimpse into the intricate interactions between biomolecules on a structured surface.
Chemical Biology Research: Within the realm of chemical biology, 5-Hexynoic NHS ester emerges as a key player in introducing alkyne functionalities into small molecules and peptides, paving the way for click chemistry-based studies of biological interactions. By tagging molecules with alkyne groups, researchers gain insights into cellular pathways and identify potential drug targets, propelling advancements in drug discovery and development.
5-hexynoic NHS ester
Required fields are marked with *
5-hexynoic NHS ester
Required fields are marked with *
Contact our experts today for pricing and comprehensive details on our ADC offerings.
From cytotoxin synthesis to linker design, discover our specialized services that complement your ADC projects.
Learn more about payload design, linker strategies, and integrated CDMO support through our curated ADC content.
Find exactly what your project needs from our expanded range of ADCs, offering flexible options to fit your timelines and goals.
Loading......
