Name: (2S,3R)-H-Abu(3-N3)-OH hydrochloride
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

(2S,3R)-2-amino-3-azidobutanoic acid hydrochloride; Butanoic acid, 2-amino-3-azido-, hydrochloride (1:1), (2S,3R)-; (2S,3R) H-Abu(3-N3) HCl; H-Abu(3-N3).HCl (2S,3R); H-Abu(3-N3)-OH HCl (2S,3R)

IUPAC Name

(2S,3R)-2-amino-3-azidobutanoic acid;hydrochloride

Canonical SMILES

C[C@H]([C@@H](C(=O)O)N)N=[N+]=[N-].Cl

InChI

InChI=1S/C4H8N4O2.ClH/c1-2(7-8-6)3(5)4(9)10;/h2-3H,5H2,1H3,(H,9,10);1H/t2-,3+;/m1./s1

InChIKey

MWINUACJIVWJPZ-MUWMCQJSSA-N

Storage

Store at 2-8 °C

(2S,3R)-H-Abu(3-N3)-OH (hydrochloride), a versatile compound with diverse applications in biochemical and pharmacological research. Here are four key applications presented with high perplexity and burstiness:

Peptide Synthesis: An integral component of peptide synthesis, this compound serves as a crucial building block thanks to its unique stereochemistry. This uniqueness enables the construction of peptides with specific configurations essential for investigating protein interactions and functions. Researchers leverage this compound to innovate novel peptides with potential as pharmaceuticals or biochemical tools, pushing the boundaries of peptide science.

Chemical Biology: Within the realm of chemical biology, scientists harness (2S,3R)-H-Abu(3-N3)-OH (hydrochloride) for synthesizing modified biomolecules. By incorporating this azide-containing amino acid into proteins, researchers unlock the door to bioorthogonal reactions such as click chemistry in living cells. This enables the labeling and modification of proteins, crucial for real-time tracking of protein dynamics and cellular processes, shedding light on the intricate workings of biological systems.

Drug Development: Found at the forefront of drug discovery, (2S,3R)-H-Abu(3-N3)-OH (hydrochloride) plays a pivotal role in exploring structure-activity relationships in peptide-based therapeutics. The azide group present in this compound facilitates easy modifications, aiding in the development of drug candidates with enhanced pharmacokinetic properties. This streamlined process allows for the creation of targeted therapies tailored to combat various diseases, promising breakthroughs in the field of medicine.

Proteomics: In the domain of proteomics, this compound serves as a cornerstone in the development of affinity tags and probes. Researchers incorporate it into peptide sequences to design effective tagging strategies for protein purification and identification. Through this methodology, a comprehensive analysis of protein expression, interactions, and functions within complex biological samples is made possible, driving forward our understanding of proteomic landscapes.