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CAS No.: 98604-89-8
Cat No.: BADC-00375
Purity: ≥98%
4.5 
1-{[4-({4-[(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy]-4-oxobutyl}disulfanyl)butanoyl]oxy}-2,5-dioxopyrrolidine-3-sulfonic acid is a disulfide-containing crosslinker or linker building block for redox-responsive bioconjugation and ADC-related linker design. The disulfide bond provides a reduction-sensitive element, while the terminal reactive groups enable attachment to appropriately functionalized biomolecules or small-molecule partners. The molecule uses nhs/succinimidyl ester (amine-reactive) for antibody lysines/primary amines (common orientation) on one side and disulfide-containing linker terminus; orientation depends on the second functional group and may require a thiol-bearing payload on the other, with disulfide trigger with c4/alkyl spacer segment providing the spacer/cleavable region. Conjugation orientation and reduction sensitivity should be evaluated in the context of the final construct because local substitution and neighboring groups can influence disulfide behavior.
![1-{[4-({4-[(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy]-4-oxobutyl}disulfanyl)butanoyl]oxy}-2,5-dioxopyrrolidine-3-sulfonic acid](https://resource.bocsci.com/structure/98604-89-8.gif)
Structure of 98604-89-8
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1-{[4-({4-[(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy]-4-oxobutyl}disulfanyl)butanoyl]oxy}-2,5-dioxopyrrolidine-3-sulfonic acid
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1-{[4-({4-[(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy]-4-oxobutyl}disulfanyl)butanoyl]oxy}-2,5-dioxopyrrolidine-3-sulfonic acid
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