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CAS No.:
Cat No.: BADC-01333
Purity: >98.0%
4.5 
Tetrazine-PEG6-amine (hydrochloride) is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Tetrazine-PEG6-amine hydrochloride is a highly versatile ADC linker intermediate designed for advanced antibody-drug conjugate (ADC) construction and targeted bioconjugation. Featuring a tetrazine reactive group, a PEG6 spacer, and a terminal amine hydrochloride, this linker enables rapid and selective bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) reactions for site-specific attachment of ADC cytotoxins. The PEG6 spacer provides enhanced solubility, flexibility, and reduces steric hindrance during conjugation. In ADC linker design, Tetrazine-PEG6-amine hydrochloride preserves antibody integrity while facilitating modular payload attachment, supporting efficient intracellular delivery and improved pharmacokinetic behavior.
In payload conjugation applications, Tetrazine-PEG6-amine hydrochloride is compatible with a wide range of ADC cytotoxins, including microtubule inhibitors, DNA-interacting agents, and other potent therapeutic payloads. The tetrazine group reacts selectively with trans-cyclooctene (TCO)-functionalized payloads under mild conditions, enabling fast, site-specific conjugation with high yield. The PEG6 spacer enhances solubility and reduces aggregation, while the terminal amine allows additional chemical modifications or secondary conjugation strategies. Researchers can use this linker to construct homogeneous, stable ADCs with predictable intracellular payload release and optimized therapeutic profiles.
From an application perspective, Tetrazine-PEG6-amine hydrochloride is widely applied in oncology-focused ADC research, protein bioconjugation studies, and modular drug delivery system development. Its combination of tetrazine reactivity, hydrophilic PEG6 spacer, and terminal amine functionality ensures efficient, site-specific conjugation while preserving antibody function. Employing this linker in ADC designs allows the creation of high-performance, customizable linker-payload conjugates capable of precise tumor targeting and controlled payload release within complex cellular environments.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01327 | Tetrazine-PEG4-amine hydrochloride | 2752945-36-9 | |
| BADC-01329 | Tetrazine-PEG4-oxyamine hydrochloride | ||
| BADC-01330 | Tetrazine-PEG4-SS-NHS | ||
| BADC-01331 | Tetrazine-PEG4-SS-Py | ||
| BADC-01332 | Tetrazine-PEG5-SS-amine | ||
| BADC-01870 | Tetrazine-PEG7-amine hydrochloride | ||
| BADC-01326 | Tetrazine-diazo-PEG4-biotin | ||
| BADC-01328 | Tetrazine-PEG4-biotin |
What is Tetrazine-PEG6-amine hydrochloride and its function in ADCs?
Tetrazine-PEG6-amine hydrochloride is a bioorthogonal linker for site-specific ADC conjugation. The tetrazine moiety reacts rapidly with trans-cyclooctene groups, while the PEG6 segment improves aqueous solubility and reduces steric hindrance, enhancing bioconjugation efficiency.
12/8/2021
Could you explain how Tetrazine-PEG6-amine hydrochloride improves ADC conjugation?
This linker facilitates rapid inverse electron-demand Diels-Alder (IEDDA) reactions with TCO-functionalized payloads or antibodies. Its hydrophilic PEG6 spacer reduces aggregation, maintains antibody activity, and allows precise control over drug-antibody ratio.
13/12/2019
Could you advise which factors affect Tetrazine-PEG6-amine hydrochloride performance?
Factors include pH, temperature, and solvent composition during conjugation. Maintaining mild, aqueous-compatible conditions ensures high reaction rates and preserves the structural integrity of both antibody and payload.
24/5/2022
Dear team, what types of payloads are compatible with Tetrazine-PEG6-amine hydrochloride?
Tetrazine-PEG6-amine hydrochloride is compatible with payloads bearing trans-cyclooctene or strained alkene groups. This enables modular ADC assembly with a variety of cytotoxic drugs, fluorescent probes, or imaging agents.
4/4/2019
Dear BOC Sciences, how should Tetrazine-PEG6-amine hydrochloride be stored to ensure long-term stability?
Tetrazine-PEG6-amine hydrochloride should be stored at -20°C in a tightly sealed container under inert atmosphere. Avoid moisture, prolonged light exposure, and repeated freeze-thaw cycles to maintain its reactive tetrazine moiety and ensure reproducible conjugation efficiency in ADC applications.
10/10/2022
— Dr. Natalie Brown, Bioconjugation Scientist (USA)
Tetrazine-PEG6-amine hydrochloride enabled highly efficient bioorthogonal conjugation reactions.
24/5/2022
— Prof. Henrik Larsen, Medicinal Chemist (Denmark)
The PEG6 spacer improved solubility and flexibility, facilitating conjugation of bulky payloads.
10/10/2022
— Dr. Sofia Moretti, Protein Chemist (Italy)
BOC Sciences delivered Tetrazine-PEG6-amine hydrochloride with high purity and full analytical support.
4/4/2019
— Ms. Emily Thompson, R&D Manager (UK)
Using this linker, we achieved reproducible ADC yields and minimal side reactions.
12/8/2021
— Dr. Marcus Schmidt, Bioconjugation Specialist (Germany)
Excellent solubility and reactivity made high-throughput screening seamless.
— Mr. Daniel Johnson, Research Scientist (Canada)
The linker consistently performed well in intracellular release and bioorthogonal reactions.
13/12/2019
Tetrazine-PEG6-amine hydrochloride
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Tetrazine-PEG6-amine hydrochloride
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