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| Catalog Number | Size | Price | Quantity | |
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| BADC-01997 | -- | $-- | Inquiry |
N3-Dab(Boc)-OH, also known as N3-Boc-3-amino-1,4-diaminobutane, is a key intermediate in organic and medicinal chemistry, commonly used in the synthesis of peptides, peptide mimetics, and other bioactive compounds. The Boc (tert-butoxycarbonyl) protecting group is widely used to protect amino groups during peptide synthesis, making N3-Dab(Boc)-OH an important building block in the development of peptide-based therapeutics. Its structure allows for easy modification and integration into larger peptide sequences, facilitating the design of compounds with specific biological activity.
One of the primary applications of N3-Dab(Boc)-OH is in peptide synthesis, particularly when synthesizing peptides with complex sequences or those requiring specific modifications. The Boc group protects the amino group, preventing unwanted reactions during peptide elongation. N3-Dab(Boc)-OH is used as a precursor for incorporating the 3-amino-1,4-diaminobutane (Dab) unit into peptides, which is valuable in the creation of peptides with enhanced stability, cell permeability, or resistance to enzymatic degradation. This makes N3-Dab(Boc)-OH essential for developing peptides for pharmaceutical applications, including targeted therapies and hormone mimetics.
N3-Dab(Boc)-OH is also crucial in the design of peptide conjugates, where it can be used to link peptides to other molecules such as drugs, diagnostic agents, or targeting ligands. The reactive amine group in N3-Dab(Boc)-OH allows for the conjugation of various bioactive compounds, creating peptide-drug conjugates (PDCs) or peptide-targeting agents. These conjugates can improve the pharmacokinetics, selectivity, and efficacy of the therapeutic peptides, making N3-Dab(Boc)-OH an important tool in the development of novel drug delivery systems.
Another significant application of N3-Dab(Boc)-OH is in the synthesis of peptide mimetics and small molecule inhibitors. By incorporating the Dab unit into non-peptidic frameworks, researchers can design peptide-like molecules that retain the biological activity of the original peptides while offering improved stability and oral bioavailability. N3-Dab(Boc)-OH serves as a key precursor for creating these mimetics, which are often used in drug discovery to develop inhibitors of protein-protein interactions, enzymes, or receptors. This enhances the versatility of N3-Dab(Boc)-OH in pharmaceutical research.
In addition, N3-Dab(Boc)-OH plays a role in the synthesis of functionalized polymers and materials. By incorporating the Dab unit into polymeric chains, it is possible to design polymers with specific bioactivity or controlled release properties. N3-Dab(Boc)-OH is often used as a monomer in the preparation of functional polymers for drug delivery, tissue engineering, or biosensors. The amine group in the Dab residue allows for further functionalization, making these materials versatile for biomedical and industrial applications.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
