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N-(2-azidoacetyl)glycine DCHA salt

  CAS No.: 855750-87-7   Cat No.: BADC-01965   Purity: > 98% 4.5  

N-(2-azidoacetyl)glycine DCHA salt acts as a reactive ADC linker component with azide functionality, facilitating click chemistry conjugation. It improves the assembly and stability of antibody-drug conjugates for targeted cancer therapy.

N-(2-azidoacetyl)glycine DCHA salt

Structure of 855750-87-7

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ADC Linker
Molecular Formula
C4H6N4O3·C12H23N
Molecular Weight
339.40
Storage
Store at 2-8 °C

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
Azido diglycine dicyclohexylamine salt; N3-Gly-Gly-OH DCHA
Melting Point
162-165°C(Dec.)
Appearance
White crystalline powder
Storage
Store at 2-8 °C

N-(2-azidoacetyl)glycine DCHA salt, a specialized chemical compound with remarkable applications in chemical biology and materials science, is a versatile tool with diverse uses.

Click Chemistry: Renowned for its azide functional groups, N-(2-azidoacetyl)glycine DCHA salt plays a pivotal role in click chemistry reactions. These groups readily engage in cycloaddition reactions with alkynes, yielding stable triazole linkages. This property elevates its significance in bioconjugation, enabling the proficient attachment of biomolecules to various surfaces and materials, fostering a wide array of applications.

Biochemical Labeling: Leveraging its azide groups, this compound allows for the introduction of distinctive modifications in biomolecules post-synthesis. By clicking azido-labeled biomolecules with fluorescent or affinity tags, researchers can delve into protein localization, interactions, and functionality within living cells. This selective labeling capability catalyzes advancements in proteomics and cellular dynamics research, offering insights that deepen our understanding of biological processes.

Polymer Chemistry: Within the domain of materials science, N-(2-azidoacetyl)glycine DCHA salt simplifies the functionalization of polymers through azide-alkyne cycloaddition. This application empowers the creation of custom-tailored polymeric materials with specialized properties, tailored for specific applications. By undergoing modification, polymers can acquire functionalities such as responsiveness to environmental cues or precise binding specificity, broadening their utility in diverse industries.

Drug Development: In the realm of pharmaceutical research, N-(2-azidoacetyl)glycine DCHA salt emerges as a key player in developing targeted drug delivery systems. Facilitating the attachment of small molecule drugs to biomolecules through click chemistry, this compound enhances drug efficacy and minimizes side effects. By conjugating drugs to proteins or peptides with precision, researchers can craft targeted therapies for conditions like cancer, where specific cell targeting is pivotal for therapeutic success.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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