Name: Folate-PEG3-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

Folate-PEG3-amine; (S)-1-amino-16-(4-((2-amino-4-hydroxypteridin-6-yl)methylamino)benzamido)-13-oxo-3,6,9-trioxa-12-azaheptadecan-17-oic acid

IUPAC Name

(2S)-5-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethylamino]-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-oxopentanoic acid

Canonical SMILES

C1=CC(=CC=C1C(=O)NC(CCC(=O)NCCOCCOCCOCCN)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N

InChI

InChI=1S/C27H37N9O8/c28-7-9-42-11-13-44-14-12-43-10-8-30-21(37)6-5-20(26(40)41)34-24(38)17-1-3-18(4-2-17)31-15-19-16-32-23-22(33-19)25(39)36-27(29)35-23/h1-4,16,20,31H,5-15,28H2,(H,30,37)(H,34,38)(H,40,41)(H3,29,32,35,36,39)/t20-/m0/s1

InChIKey

GZQSIWKWWBLFGU-FQEVSTJZSA-N

Folate-PEG3-amine, a versatile compound with diverse applications in bioscience and medicine, plays a pivotal role in various cutting-edge advancements. Here are four key applications of Folate-PEG3-amine:

Targeted Drug Delivery: Folate-PEG3-amine stands at the forefront of targeted drug delivery innovations, particularly in cancer therapy. By conjugating therapeutic drugs to Folate-PEG3-amine, scientists can specifically target cancer cells that exhibit elevated folate receptors, thus amplifying treatment effectiveness while mitigating adverse effects. This precision targeting strategy enhances drug accumulation in tumors while minimizing impact on healthy tissues.

Diagnostic Imaging: In the realm of medical diagnostics, Folate-PEG3-amine emerges as a critical component for enhanced tumor detection. Through conjugation with imaging agents, Folate-PEG3-amine facilitates accurate tumor localization in imaging modalities such as PET and fluorescence imaging. This strategic coupling not only improves tumor visualization but also aids in early cancer detection and treatment planning, showcasing the transformative potential of this compound in diagnostic medicine.

Functional Nanoparticles: Folate-PEG3-amine assumes a pivotal role in the development of functionalized nanoparticles for diverse biomedical applications. By coating nanoparticles with Folate-PEG3-amine, researchers engineer systems that precisely target and deliver therapeutic agents to specific cell types, revolutionizing drug delivery strategies. This sophisticated functionalization approach enhances the specificity and efficiency of nanoparticle-based therapies.

Bioconjugation Research: Renowned for its versatility, Folate-PEG3-amine finds extensive utility in bioconjugation research, facilitating the linking of biomolecules such as peptides, proteins, and antibodies to targeting moieties or therapeutic agents. The inclusion of the PEG3 spacer imparts flexibility and reduces steric hindrance, enabling efficient binding and interactions. This application plays a crucial role in the creation of multifunctional bioconjugates for both research and therapeutic applications.