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CAS No.: 710323-40-3
Cat No.: BADC-01525
4.5 
Folate-PEG3-amine is a highly complex biological small molecule that shows great potential in combating various diseases through its precise receptor targeting mechanism. The conjugate, which represents a mixture of folic acid (a valuable vitamin B9 derivative) and polyethylene glycol (PEG), offers unparalleled opportunities for drug delivery systems, cancer treatments and even imaging agents.
Structure of 710323-40-3
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Folate-PEG3-amine, a versatile compound with diverse applications in bioscience and medicine, plays a pivotal role in various cutting-edge advancements. Here are four key applications of Folate-PEG3-amine:
Targeted Drug Delivery: Folate-PEG3-amine stands at the forefront of targeted drug delivery innovations, particularly in cancer therapy. By conjugating therapeutic drugs to Folate-PEG3-amine, scientists can specifically target cancer cells that exhibit elevated folate receptors, thus amplifying treatment effectiveness while mitigating adverse effects. This precision targeting strategy enhances drug accumulation in tumors while minimizing impact on healthy tissues.
Diagnostic Imaging: In the realm of medical diagnostics, Folate-PEG3-amine emerges as a critical component for enhanced tumor detection. Through conjugation with imaging agents, Folate-PEG3-amine facilitates accurate tumor localization in imaging modalities such as PET and fluorescence imaging. This strategic coupling not only improves tumor visualization but also aids in early cancer detection and treatment planning, showcasing the transformative potential of this compound in diagnostic medicine.
Functional Nanoparticles: Folate-PEG3-amine assumes a pivotal role in the development of functionalized nanoparticles for diverse biomedical applications. By coating nanoparticles with Folate-PEG3-amine, researchers engineer systems that precisely target and deliver therapeutic agents to specific cell types, revolutionizing drug delivery strategies. This sophisticated functionalization approach enhances the specificity and efficiency of nanoparticle-based therapies.
Bioconjugation Research: Renowned for its versatility, Folate-PEG3-amine finds extensive utility in bioconjugation research, facilitating the linking of biomolecules such as peptides, proteins, and antibodies to targeting moieties or therapeutic agents. The inclusion of the PEG3 spacer imparts flexibility and reduces steric hindrance, enabling efficient binding and interactions. This application plays a crucial role in the creation of multifunctional bioconjugates for both research and therapeutic applications.
What is Folate-PEG3-amine used for in targeted ADCs?
Folate-PEG3-amine is a functional linker that targets folate receptor-expressing cells. The PEG3 spacer improves solubility and reduces steric hindrance, while the terminal amine provides a reactive site for conjugation with cytotoxins or imaging agents in ADC development.
2/7/2017
Dear team, how does Folate-PEG3-amine achieve cell-specific targeting?
The folate moiety binds specifically to folate receptors, which are overexpressed in many tumor types. This selective binding facilitates receptor-mediated internalization of ADCs, enhancing targeted delivery of cytotoxic payloads to cancer cells.
12/3/2017
Dear team, what types of payloads can be linked to Folate-PEG3-amine?
The terminal amine reacts with activated esters or maleimide groups on payloads, allowing conjugation of small molecule drugs, imaging agents, or fluorophores. The PEG spacer ensures accessibility and reduces steric constraints during coupling.
21/12/2022
Dear BOC Sciences, what are the recommended storage conditions for Folate-PEG3-amine?
Store under desiccated conditions at low temperature to preserve chemical integrity. Protect from light and moisture to maintain the folate functionality and reactivity of the terminal amine for consistent conjugation performance.
7/8/2022
Dear team, what are the considerations for solubility and handling of Folate-PEG3-amine?
Folate-PEG3-amine is soluble in aqueous buffers and common organic solvents such as DMSO. Handling should minimize exposure to light and air to prevent oxidation. For long-term storage, maintain at -20°C in a desiccated container and avoid multiple freeze-thaw cycles to preserve functional amine groups for bioconjugation.
5/1/2017
— Dr. Olivia Brown, Medicinal Chemist (UK)
Folate-PEG3-amine enabled efficient targeting moiety incorporation into our ADC constructs.
21/12/2022
— Ms. Anna Schmidt, Biochemist (Germany)
Excellent solubility and stability allowed smooth multi-step synthesis.
5/1/2017
— Dr. William Parker, ADC Scientist (USA)
High purity and lot-to-lot consistency made synthesis predictable and reliable.
7/8/2022
— Dr. Elise Moreau, Senior Chemist (France)
Integration into our linker workflow was seamless, saving valuable development time.
2/7/2017
— Dr. Liam Fischer, Chemist (UK)
Folate-PEG3-amine facilitated novel ADC designs enhancing solubility and targeting.
— Dr. Robert Green, Medicinal Chemist (UK)
Folate-PEG3-amine enabled efficient targeting ligand conjugation for our delivery studies. Excellent purity and solubility facilitated our workflow.
12/3/2017
Folate-PEG3-amine
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Folate-PEG3-amine
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