Name: Mc-Val-Ala-PAB
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Synonyms

6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide

IUPAC Name

Canonical SMILES

CC(C)C(C(=O)NC(C)C(=O)NC1=CC=C(C=C1)CO)NC(=O)CCCCCN2C(=O)C=CC2=O

InChI

InChI=1S/C25H34N4O6/c1-16(2)23(28-20(31)7-5-4-6-14-29-21(32)12-13-22(29)33)25(35)26-17(3)24(34)27-19-10-8-18(15-30)9-11-19/h8-13,16-17,23,30H,4-7,14-15H2,1-3H3,(H,26,35)(H,27,34)(H,28,31)/t17-,23-/m0/s1

InChIKey

DAMSURYLURICHN-SBUREZEXSA-N

Solubility

10 mm in DMSO

Appearance

Solid

Shelf Life

≥ 2 years

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Form

Solid

Mc-Val-Ala-PAB, a key linker molecule in drug delivery and bioconjugation, boasts diverse applications across various domains.

Targeted Drug Delivery: Central to antibody-drug conjugate (ADC) development, Mc-Val-Ala-PAB linkers serve as essential components for precisely ferrying chemotherapeutic agents to cancerous cells. By maintaining drug dormancy until reaching the target site, these linkers minimize adverse effects and optimize treatment efficacy.

Prodrug Development: In the realm of pharmacology, Mc-Val-Ala-PAB linkers are pivotal for designing prodrugs that activate under specific conditions, enhancing drug stability and enabling targeted activation within the body. This innovative approach enables concentrated drug delivery to diseased tissues while minimizing systemic toxicity, reshaping conventional drug administration practices for better outcomes.

Bioconjugation Techniques: Researchers utilize Mc-Val-Ala-PAB linkers in bioconjugation efforts to attach therapeutic agents like proteins and oligonucleotides to specific biomolecules. This strategic binding technique is essential for crafting precision-targeted therapeutics and diagnostics, enhancing bioactive compound bioavailability and accuracy through stable and specific couplings.

Peptide-based Drug Design: Mc-Val-Ala-PAB serves as a cornerstone in the peptide-based drug design landscape, facilitating the conjugation of peptides with small molecules or larger proteins to improve their pharmacokinetic properties. These linkages enhance the stability and delivery efficiency of peptide drugs, boosting their effectiveness in combating diseases and propelling advancements in personalized medicine.