Synonyms
Azadibenzocyclooctyne acid; 6-(11,12-Didehydro-5,6-dihydrodibenzo[b,f]azocine-5-yl)-6-oxohexanoic acid
Canonical SMILES
C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCCCC(=O)O
InChI
InChI=1S/C21H19NO3/c23-20(11-5-6-12-21(24)25)22-15-18-9-2-1-7-16(18)13-14-17-8-3-4-10-19(17)22/h1-4,7-10H,5-6,11-12,15H2,(H,24,25)
InChIKey
NIRLBCOFKPVQLM-UHFFFAOYSA-N
Flash Point
337.5±31.5 °C
Index Of Refraction
1.654
Vapor Pressure
0.0±2.0 mmHg at 25°C
Biological Activity
DBCO-C6-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be used in the synthesis of carmaphycin analogues[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Appearance
white to slight grey solid
Shelf Life
0-4℃ for short term (days to weeks), or -20℃ for long term (months).
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Boiling Point
634.4±55.0 °C at 760 mmHg
