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Azido-PEG9-amine

  CAS No.: 1207714-69-9   Cat No.: BADC-00901   Purity: ≥95% 4.5  

Azido-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Azido-PEG9-amine

Structure of 1207714-69-9

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Category
ADC Linker
Molecular Formula
C20H42N4O9
Molecular Weight
482.58
Shipping
Room temperature
Shipping
Store at 2-8°C

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
N3-PEG9-CH2CH2NH2; Azido-PEG9-NH2; N3-PEG9-NH2; 29-azido-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-amine; 1-Amino-29-azido-3,6,9,12,15,18,21,24,27-nonaoxanonacosane
IUPAC Name
2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Canonical SMILES
C(COCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])N
InChI
InChI=1S/C20H42N4O9/c21-1-3-25-5-7-27-9-11-29-13-15-31-17-19-33-20-18-32-16-14-30-12-10-28-8-6-26-4-2-23-24-22/h1-21H2
InChIKey
QECAUUOGHAUEDJ-UHFFFAOYSA-N
Solubility
Soluble in DCM, DMF, DMSO, Water
Appearance
Colorless Oily Matter
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature
Storage
Store at 2-8°C

Azido-PEG9-amine, a highly versatile compound in the realms of bioconjugation and molecular biology, boasts a multitude of applications. Here are four key applications of Azido-PEG9-amine, presented with elevated perplexity and burstiness.

Bioconjugation: Azido-PEG9-amine serves as a pivotal agent for linking biomolecules such as proteins, peptides, and nucleic acids together. Its azide group facilitates seamless conjugation via click chemistry reactions, serving as an efficient instrument for the construction of intricate bioconjugates. These diverse conjugates find utility in various realms, including drug delivery, diagnostics, and therapeutic exploration.

Protein Labeling: Within the field of protein analysis, Azido-PEG9-amine assumes a critical role in protein labeling for the purposes of imaging and tracking. By attaching fluorescent dyes or other probes to proteins through the use of Azido-PEG9-amine, researchers can visualize and track protein interactions and localization within cells. This aids in enhancing our comprehension of protein functionalities and cellular processes through a visual lens.

Surface Functionalization: Azido-PEG9-amine emerges as a powerful tool for altering the surfaces of nanoparticles and other materials to bolster their biocompatibility and functionality. This tailored surface modification facilitates precise interactions with target molecules or cells, finding applicability in biosensing, targeted drug delivery, and the coating of medical devices. The enhanced properties of these functionalized surfaces can be tailored to cater to a diverse array of biomedical applications.

Drug Delivery Systems: In the domain of drug delivery research, Azido-PEG9-amine plays a pivotal role in the development of PEGylated drug carriers. The integration of the polyethylene glycol (PEG) chain aids in amplifying the solubility, stability, and circulation time of therapeutic compounds. This augmentation in drug carriers can lead to heightened efficacy and reduced side effects of various drugs by ensuring controlled and targeted delivery mechanisms.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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