Name: Azido-PEG7-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

Amino-PEG7-azide; 23-azido-3,6,9,12,15,18,21-heptaoxatricosan-1-amine; Azido-PEG7-NH2; N3-PEG7-CH2CH2NH2; N3-PEG7-NH2

IUPAC Name

2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine

Canonical SMILES

C(COCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])N

InChI

InChI=1S/C16H34N4O7/c17-1-3-21-5-7-23-9-11-25-13-15-27-16-14-26-12-10-24-8-6-22-4-2-19-20-18/h1-17H2

InChIKey

VZKXLNRXAFTBOW-UHFFFAOYSA-N

Solubility

Soluble in Chloroform (Slightly), Methanol (Slightly)

PSA

140.38000

Appearance

Light Yellow to Light Beige Oily Matter

Shipping

Room temperature

Storage

Store at 2-8°C under inert atmosphere

Pictograms

Irritant

Signal Word

Warning

Biological Activity

Azido-PEG7-amine is a non-cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Azido-PEG7-amine is a versatile compound used in various biochemical and biotechnological applications. Here are some key applications of Azido-PEG7-amine:

Bioconjugation: Azido-PEG7-amine is commonly employed in bioconjugation techniques to link biomolecules through click chemistry reactions. This compound is particularly useful in labeling proteins, peptides, and nucleotides without affecting their biological activity. The resulting conjugates are used in various assays, imaging studies, and therapeutic applications.

Drug Delivery Systems: Azido-PEG7-amine is utilized in the development of targeted drug delivery systems. By attaching azido-PEG7-amine to therapeutic molecules, researchers can create prodrugs or drug carriers that are activated under specific conditions, such as within diseased tissues. This enhances the specificity and efficacy of treatments while minimizing side effects.

Nanoparticle Functionalization: In nanotechnology, Azido-PEG7-amine is used to functionalize the surface of nanoparticles, enhancing their stability and biocompatibility. The azido group allows for further modification using click chemistry, enabling the attachment of targeting ligands, fluorescent markers, or drug molecules. These functionalized nanoparticles can be used for targeted drug delivery, imaging, and diagnostic applications.

Biosensor Development: Azido-PEG7-amine is instrumental in the creation of biosensors, where it is used to anchor biorecognition elements onto sensor surfaces. By linking antibodies, enzymes, or other biomolecules to the sensor through Azido-PEG7-amine, researchers can develop highly specific and sensitive detection systems. These biosensors are applied in medical diagnostics, environmental monitoring, and food safety testing.