Name: CHO-Ph-CONH-PEG1-NHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

Ald-Ph-amido-PEG1-C2-NHS ester; 2,5-dioxopyrrolidin-1-yl 3-(2-(4-formylbenzamido)ethoxy)propanoate; Propanoic acid, 3-[2-[(4-formylbenzoyl)amino]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester; N-(2-{3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy}ethyl)-4-formylbenzamide; Benzamide, N-[2-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]ethyl]-4-formyl-

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[(4-formylbenzoyl)amino]ethoxy]propanoate

Canonical SMILES

C1CC(=O)N(C1=O)OC(=O)CCOCCNC(=O)C2=CC=C(C=C2)C=O

InChI

InChI=1S/C17H18N2O7/c20-11-12-1-3-13(4-2-12)17(24)18-8-10-25-9-7-16(23)26-19-14(21)5-6-15(19)22/h1-4,11H,5-10H2,(H,18,24)

InChIKey

ONVNDJSKJDFLTF-UHFFFAOYSA-N

Density

1.4±0.1 g/cm3

Solubility

Soluble in DMSO

Shipping

Room temperature, or blue ice upon request.

Storage

Store at 2-8°C

CHO-Ph-CONH-PEG1-NHS ester, a versatile reagent essential for bioconjugation and medical research, finds diverse applications in various fields. Here are four key applications:

Protein Labeling: Widely employed for covalently labeling proteins and peptides, CHO-Ph-CONH-PEG1-NHS ester interacts with primary amines on proteins through its NHS ester group, facilitating the attachment of PEG moieties. This modification enhances the solubility, stability, and pharmacokinetics of the labeled proteins, showcasing its potential for advancing protein research and drug development.

Surface Functionalization: In the realm of biomaterials, CHO-Ph-CONH-PEG1-NHS ester plays a crucial role in surface functionalization. By linking PEG chains to surfaces, it minimizes non-specific protein adsorption and boosts biocompatibility, particularly beneficial for creating bio-compatible implants, sensors, and medical devices. This application underscores the versatility and significance of this reagent in enhancing material performance.

Drug Delivery Systems: Engaging in the design of cutting-edge drug delivery systems, CHO-Ph-CONH-PEG1-NHS ester enables the conjugation of therapeutic agents to PEGylated carriers. This integration enhances drug solubility and circulation time in the bloodstream, reducing the need for frequent administration and mitigating potential drug side effects, offering a promising avenue for improving patient care and treatment outcomes.

Diagnostic Assays: Playing a pivotal role in diagnostic assay development, CHO-Ph-CONH-PEG1-NHS ester enhances the sensitivity and specificity of assays by coupling it with detection antibodies or probes. This enhancement contributes to the optimization of diagnostic tests used in medical and research settings, emphasizing its value in advancing diagnostic capabilities and healthcare practices.