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8-Azido-3,6-dioxaoctanoic acid cyclohexylammonium salt

  CAS No.: 2098500-94-6   Cat No.: BADC-01983   Purity: ≥99% by HPLC 4.5  

8-Azido-3,6-dioxaoctanoic acid cyclohexylammonium salt is an azide-functionalized ADC linker building block enabling bioorthogonal click chemistry for efficient antibody-payload conjugation, enhancing the selectivity and stability of antibody-drug conjugates.

8-Azido-3,6-dioxaoctanoic acid cyclohexylammonium salt

Structure of 2098500-94-6

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ADC Linker
Molecular Formula
C12H24N4O4
Molecular Weight
288.34
Storage
Store at 2-8 °C

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
N3-AEEA.CHA; N3-AEEAc.CHA; [2-(2-Azidoethoxy)ethoxy]acetic acid cyclohexylamine salt; N3-AEEA CHA; Azido-PEG2-acetic Acid CHA Salt; 2-[2-(2-Azidoethoxy)ethoxy]acetic Acid Cyclohexylamine Salt; Acetic acid, 2-[2-(2-azidoethoxy)ethoxy]-, compd. with cyclohexanamine (1:1); N3 AEEA CHA
IUPAC Name
2-[2-(2-azidoethoxy)ethoxy]acetic acid;cyclohexanamine
Canonical SMILES
C1CCC(CC1)N.C(COCCOCC(=O)O)N=[N+]=[N-]
InChI
InChI=1S/C6H11N3O4.C6H13N/c7-9-8-1-2-12-3-4-13-5-6(10)11;7-6-4-2-1-3-5-6/h1-5H2,(H,10,11);6H,1-5,7H2
InChIKey
CVGMGYQHORMPPJ-UHFFFAOYSA-N
Melting Point
72-78 °C
Appearance
White crystalline powder
Storage
Store at 2-8 °C

8-Azido-3,6-dioxaoctanoic acid cyclohexylammonium salt, a versatile compound with diverse applications in chemical biology and materials science, boasts a spectrum of utility. Here are four key applications presented with high perplexity and burstiness:

Bioconjugation: Employing its azide group, this compound finds widespread use in bioconjugation methodologies, engaging in click chemistry reactions. Researchers leverage it to affix biomolecules like proteins, nucleic acids, or small molecules onto various substrates or other biomolecules. This process is integral in crafting targeted drug delivery systems and diagnostic instruments, ushering in new frontiers in biological research.

Chemical Biology: Within the realm of chemical biology, 8-Azido-3,6-dioxaoctanoic acid cyclohexylammonium salt plays a pivotal role as a photoaffinity label. When exposed to UV irradiation, it forms covalent bonds with nearby biomolecules, enabling the scrutiny of protein interactions and functional mapping. This innovative technique aids in identifying binding partners of small molecules and unraveling intricate biological pathways, illuminating the complexities of molecular interactions.

Polymer Chemistry: This compound is a vital component in the synthesis of functionalized polymers. Its azide group seamlessly integrates into polymer frameworks, facilitating additional functionalization through click chemistry. This application drives the development of novel materials with tailored properties, essential for applications like drug delivery systems and bio-compatible implants, expanding the horizons of polymer science.

Surface Modification: In the domain of surface modification, 8-Azido-3,6-dioxaoctanoic acid cyclohexylammonium salt is a key player in enhancing surface bioactivity. Through its attachment capabilities, biological motifs can be grafted onto surface coatings, improving cell adhesion or thwarting microbial proliferation. Such advancements are pivotal in the realm of medical device fabrication and biosensor enhancement, propelling innovations in biotechnology.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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