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(2S)-N3-IsoSer

  CAS No.: 1620171-65-4   Cat No.: BADC-01676 4.5  

(2S)-N3-IsoSer is an azide-functionalized isoserine ADC linker intermediate used for site-specific click chemistry conjugation in antibody-drug conjugates, enhancing payload stability and targeted delivery. Keywords: ADC linker, azide linker, isoserine derivative, click chemistry, targeted therapy.

(2S)-N3-IsoSer

Structure of 1620171-65-4

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ADC Linker
Molecular Formula
C3H5N3O3
Molecular Weight
131.09

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IUPAC Name
(2S)-3-azido-2-hydroxypropanoic acid
Canonical SMILES
C(C(C(=O)O)O)N=[N+]=[N-]
InChI
InChI=1S/C3H5N3O3/c4-6-5-1-2(7)3(8)9/h2,7H,1H2,(H,8,9)/t2-/m0/s1
InChIKey
NEYYWZWMFRJFDX-REOHCLBHSA-N

(2S)-N3-IsoSer, a synthetic compound with notable implications in bioscience research and pharmaceutical advancements. Here are four key applications of (2S)-N3-IsoSer presented with high perplexity and burstiness:

Drug Development: Positioned at the forefront of drug innovation, (2S)-N3-IsoSer serves as a pivotal intermediate in synthesizing a spectrum of pharmaceuticals, particularly those targeting neurological disorders. Its distinct molecular structure empowers chemists to craft groundbreaking medications with heightened efficacy and diminished side effects. This compound's role in medicinal chemistry is indispensable, catalyzing the discovery of novel therapeutic agents that push the boundaries of pharmacological interventions.

Protein Engineering: Embarking on the frontier of protein manipulation, (2S)-N3-IsoSer finds application in the modification of peptides and proteins to unravel their intricate structure and function. Through selective alteration of amino acid residues, researchers embark on a journey to decipher protein folding dynamics, stability, and interactions. This critical application fuels the development of cutting-edge protein-based therapeutics and advances our understanding of protein biochemistry, paving the way for next-generation medical treatments.

Chiral Chemistry: Diving deep into the realm of chiral chemistry, (2S)-N3-IsoSer emerges as a cornerstone for synthesizing enantiomerically pure compounds. Its stereochemical properties render it an indispensable building block in the creation of chiral drugs and agrochemicals, promising the emergence of more potent and selective pharmacological agents with minimal side effects. This endeavor in chiral chemistry opens avenues for the development of revolutionary therapies and agricultural solutions, driven by the precision and efficacy of (2S)-N3-IsoSer.

Biocatalysis: Navigating the realm of biocatalytic processes, (2S)-N3-IsoSer plays a pivotal role in augmenting the production of specific molecules through its engagement as a substrate or intermediate. By facilitating the synthesis of complex natural products and novel compounds, this synthetic compound propels advancements in green chemistry, advocating for sustainable and environmentally friendly methodologies. The strategic application of (2S)-N3-IsoSer in biocatalysis underscores its significance in driving forward innovative solutions that harmonize science with ecological consciousness.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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