(S,R,S)-AHPC-C6-PEG3-butyl-N3 - CAS 2300155-90-0

(S,R,S)-AHPC-C6-PEG3-butyl-N3 - CAS 2300155-90-0 Catalog number: BADC-01695

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(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group.

Category
ADCs Linker
Product Name
(S,R,S)-AHPC-C6-PEG3-butyl-N3
CAS
2300155-90-0
Catalog Number
BADC-01695
Molecular Formula
C38H59N7O7S
Molecular Weight
757.98

Ordering Information

Catalog Number Size Price Quantity
BADC-01695 -- $-- Inquiry
Description
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group.
IUPAC Name
(2S,4R)-1-[(2S)-2-[6-[2-[2-(6-azidohexoxy)ethoxy]ethoxy]hexanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Canonical SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCCCOCCOCCOCCCCCCN=[N+]=[N-])O
InChI
InChI=1S/C38H59N7O7S/c1-28-34(53-27-41-28)30-15-13-29(14-16-30)25-40-36(48)32-24-31(46)26-45(32)37(49)35(38(2,3)4)43-33(47)12-8-7-11-19-51-21-23-52-22-20-50-18-10-6-5-9-17-42-44-39/h13-16,27,31-32,35,46H,5-12,17-26H2,1-4H3,(H,40,48)(H,43,47)/t31-,32+,35-/m1/s1
InChIKey
DQCFIDNEYXSXHP-MEEYNGGZSA-N

(S,R,S)-AHPC-C6-PEG3-butyl-N3, a versatile chemical probe with diverse applications in chemistry and biomedicine, is a key player in cutting-edge research. Here are four crucial applications rich in perplexity and burstiness:

Protein Degradation: Serving as a crucial component in targeted protein degradation studies, this compound acts as a ligand for E3 ubiquitin ligases. Scientists utilize it to develop PROTACs (PROteolysis TArgeting Chimeras) capable of selectively degrading disease-causing proteins. This innovative strategy presents a promising avenue for treating complex conditions like cancer and neurodegenerative disorders by precisely targeting specific proteins at the molecular level.

Drug Development: (S,R,S)-AHPC-C6-PEG3-butyl-N3 plays a pivotal role in the development and synthesis of novel therapeutic agents. By conjugating this compound with different bioactive molecules, researchers can create hybrids with enhanced pharmacological properties, potentially leading to the discovery of more efficacious and targeted drugs. This versatile approach opens new doors for advancing drug development and precision medicine.

Bioconjugation: The inclusion of a PEGylation component in (S,R,S)-AHPC-C6-PEG3-butyl-N3 renders it indispensable for bioconjugation applications. PEGylation enhances the solubility and stability of biologically active compounds, making them ideal for in vivo studies. This property proves invaluable in the realm of developing peptide-based therapeutics with improved bioavailability and efficacy, contributing to the advancement of personalized medicine.

Biomedical Research: (S,R,S)-AHPC-C6-PEG3-butyl-N3 finds extensive use in diverse biomedical research endeavors, ranging from elucidating protein interactions to unraveling cellular localization mechanisms. By integrating this compound into experimental models, scientists can gain profound insights into the intricate cellular processes underpinning various diseases. This knowledge is fundamental for uncovering novel therapeutic targets and gaining a deeper understanding of disease pathogenesis, driving forward the frontiers of biomedical science.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: (S,R,S)-AHPC-C6-PEG3-butyl-N3
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