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MC-Val-Ala-PAB-PNP

  CAS No.: 1639939-40-4   Cat No.: BADC-00978   Purity: >98.0% 4.5  

MC-Val-Ala-PAB-PNP is a peptide ADC linker with maleimide for thiol conjugation and valine-alanine for protease cleavage, enabling targeted payload release in antibody-drug conjugates.

MC-Val-Ala-PAB-PNP

Structure of 1639939-40-4

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Category
ADC Linker
Molecular Formula
C32H37N5O10
Molecular Weight
651.66
Shipping
Room temperature, or blue ice upon request.
Shipping
Store at -20 °C, keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
[4-[[(2S)-2-[[(2S)-2-[6-(2,5-Dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
IUPAC Name
Canonical SMILES
CC(C)C(C(=O)N(C1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])C(C)C(=O)N)NC(=O)CCCCCN3C(=O)C=CC3=O
InChI
InChI=1S/C32H37N5O10/c1-20(2)29(34-26(38)7-5-4-6-18-35-27(39)16-17-28(35)40)31(42)36(21(3)30(33)41)23-10-8-22(9-11-23)19-46-32(43)47-25-14-12-24(13-15-25)37(44)45/h8-17,20-21,29H,4-7,18-19H2,1-3H3,(H2,33,41)(H,34,38)/t21-,29-/m0/s1
InChIKey
VMOQJVBAOUFRSX-LGGPFLRQSA-N
Solubility
10 mm in DMSO
Shelf Life
≥ 2 years
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.

MC-Val-Ala-PAB-PNP, a chemical compound utilized in bioconjugation and prodrug design, plays a pivotal role in various applications.

Prodrug Development: In the realm of prodrug development, MC-Val-Ala-PAB-PNP shines as a crucial linker that triggers the release of active drugs in response to specific enzymatic signals. This functionality allows for the creation of targeted therapies that activate precisely at the intended site, mitigating off-target effects and elevating therapeutic effectiveness. Notably, its utility in cancer treatment underscores the importance of accurate drug delivery for optimal outcomes.

Peptide Drug Conjugation: Within the domain of peptide drug conjugation, MC-Val-Ala-PAB-PNP assumes the role of a cleavable linker, facilitating the connection between therapeutic peptides and carrier molecules or medications. This connection bolsters the stability and half-life of peptide drugs, enhancing their pharmacokinetic properties. The controlled release mechanism of MC-Val-Ala-PAB-PNP ensures that peptides are liberated at the designated site, amplifying the efficacy of treatments.

Targeted Drug Delivery: MC-Val-Ala-PAB-PNP's involvement in targeted drug delivery systems is noteworthy, as it binds drugs to antibodies or other targeting agents. While remaining stable in circulation, this compound releases the drug upon binding to the designated target, such as tumor cells or specific tissue types. This targeted strategy minimizes systemic exposure and diminishes potential side effects, exemplifying precision in drug delivery.

Biochemical Research: Within biochemical research settings, MC-Val-Ala-PAB-PNP serves as a valuable tool for investigating enzyme activity and substrate specificity. Its cleavable nature provides researchers with insights into enzyme kinetics and biochemical pathways, fostering effective exploration in the field. Unveiling the interactions between MC-Val-Ala-PAB-PNP and enzymes holds the promise of identifying novel therapeutic targets and enhancing strategies for drug design.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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