Description
MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
[4-[[(2S)-2-[[(2S)-2-[6-(2,5-Dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
IUPAC Name
[4-[[(2S)-1-amino-1-oxopropan-2-yl]-[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
Canonical SMILES
CC(C)C(C(=O)N(C1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])C(C)C(=O)N)NC(=O)CCCCCN3C(=O)C=CC3=O
InChI
InChI=1S/C32H37N5O10/c1-20(2)29(34-26(38)7-5-4-6-18-35-27(39)16-17-28(35)40)31(42)36(21(3)30(33)41)23-10-8-22(9-11-23)19-46-32(43)47-25-14-12-24(13-15-25)37(44)45/h8-17,20-21,29H,4-7,18-19H2,1-3H3,(H2,33,41)(H,34,38)/t21-,29-/m0/s1
InChIKey
VMOQJVBAOUFRSX-LGGPFLRQSA-N
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.
