Name: DBCO-NH-PEG4-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

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$--

In stock

Synonyms

DBCO-PEG4-NH2;DBCO-NHCO-PEG4-amine TFA salt;DBCO-PEG4-amine;Azadibenzocyclooctyne-PEG4 amine; DBCO-PEG4 amine

IUPAC Name

3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide

Canonical SMILES

C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)CCOCCOCCOCCOCCN

InChI

InChI=1S/C29H37N3O6/c30-13-16-36-18-20-38-22-21-37-19-17-35-15-12-28(33)31-14-11-29(34)32-23-26-7-2-1-5-24(26)9-10-25-6-3-4-8-27(25)32/h1-8H,11-23,30H2,(H,31,33)

InChIKey

KTIOBJVNCOFWCL-UHFFFAOYSA-N

Density

1.2±0.1 g/cm3

Solubility

10 mm in DMSO

Flash Point

428.0±32.9 °C

Index Of Refraction

1.595

Vapor Pressure

0.0±2.7 mmHg at 25°C

Appearance

Light yellow oil

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -5°C,keep in dry and avoid sunlight.

Boiling Point

784.1±60.0 °C at 760 mmHg

The DBCO-NH-PEG4-amine reagent is a versatile tool commonly employed in bioconjugation and chemical biology. Here are four key applications of DBCO-NH-PEG4-amine:

Click Chemistry: A mainstay in click chemistry reactions, DBCO-NH-PEG4-amine plays a pivotal role in enabling the precise and effective labeling of biomolecules. By engaging with azide-functionalized compounds, it facilitates the secure attachment of probes, medications, or other functional entities to various biopolymers like proteins, antibodies, and DNA. This capability opens up a world of possibilities in bioimaging, diagnostics, and targeted drug delivery.

Drug Delivery Systems: Positioned at the forefront of drug delivery system innovation, DBCO-NH-PEG4-amine is instrumental in the design and enhancement of sophisticated drug transport mechanisms. Through click chemistry, this compound can be linked to drug-loaded nanoparticles or liposomes, bolstering their stability and biocompatibility. Such applications ensure the targeted delivery of therapeutic agents to specific cells or tissues, significantly improving treatment efficacy while minimizing potential side effects.

Surface Functionalization: A key player in surface modification for biosensor and biomedical device development, DBCO-NH-PEG4-amine showcases its versatility in creating functionalized interfaces with tailored properties. By anchoring this reagent onto surfaces, researchers can establish specialized platforms that facilitate the targeted capture and detection of biomolecules. This strategic approach is particularly advantageous in the realm of diagnostic tool development, enabling the crafting of highly sensitive instruments and elevating the performance benchmarks of biosensors to unprecedented levels.

Protein Engineering: In the intricate world of protein engineering, DBCO-NH-PEG4-amine emerges as a pivotal agent for effecting site-specific modifications on proteins. By integrating this compound into conjugation methodologies, scientists can affix a diverse array of functional groups or probes onto specified amino acid residues with precision. This precision aids in protein tagging, structural investigations, and the conceptualization of innovative protein-based therapeutics, driving forth the boundaries of biotechnological research.