DBCO-NHCO-PEG4-amine - CAS 1255942-08-5

DBCO-NHCO-PEG4-amine - CAS 1255942-08-5 Catalog number: BADC-00909

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DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively).

General Information

Category
ADCs Linker
Product Name
DBCO-NHCO-PEG4-amine
CAS
1255942-08-5
Catalog Number
BADC-00909
Molecular Formula
C29H37N3O6
Molecular Weight
523.62 g/mol
Purity
≥95%
Synonyms
Azadibenzocyclooctyne-PEG4 amine; DBCO-PEG4 amine
Solubility
10 mM in DMSO
Storage
Store at -5°C,keep in dry and avoid sunlight.
Shelf Life
0-4℃ for short term (days to weeks), or -20℃ for long term (months).
Shipping
Room temperature, or blue ice upon request.
Canonical SMILES
C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)CCOCCOCCOCCOCCN
InChI Key
KTIOBJVNCOFWCL-UHFFFAOYSA-N
InChI
InChI=1S/C29H37N3O6/c30-13-16-36-18-20-38-22-21-37-19-17-35-15-12-28(33)31-14-11-29(34)32-23-26-7-2-1-5-24(26)9-10-25-6-3-4-8-27(25)32/h1-8H,11-23,30H2,(H,31,33)

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Historical Records: SPDPH | N-(2-(4-Fluorophenoxy)ethyl)-4-Formylbenzamide | Muscarinic toxin 2 | Fmoc-Phe-Lys(Boc)-PAB-PNP | Mp-polymer ester | NHPI-PEG2-C2-NHS ester | Ald-Ph-amido-PEG1-C2-NHS ester | FR-901464 | Trachelanthamine | Mal-PEG6-NHS | DBCO-NHCO-PEG4-amine
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