DBCO-N-bis(PEG4-NHS ester) - CAS 2639395-38-1

DBCO-N-bis(PEG4-NHS ester) - CAS 2639395-38-1 Catalog number: BADC-01686

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DBCO-N-bis(PEG4-NHS ester) is a click chemistry reagent. DBCO-N-bis(PEG4-NHS ester) is a PEG linker which contains two PEG4-NHS ester and a DBCO group.

Category
ADCs Linker
Product Name
DBCO-N-bis(PEG4-NHS ester)
CAS
2639395-38-1
Catalog Number
BADC-01686
Molecular Formula
C49H62N4O18
Molecular Weight
995.03
DBCO-N-bis(PEG4-NHS ester)

Ordering Information

Catalog Number Size Price Quantity
BADC-01686 -- $--
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Description
DBCO-N-bis(PEG4-NHS ester) is a click chemistry reagent. DBCO-N-bis(PEG4-NHS ester) is a PEG linker which contains two PEG4-NHS ester and a DBCO group.
Synonyms
DBCO-N-bis(PEG4-NHS ester); BP-25449; HY-145090; CS-0356179; 2639395-38-1
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCN(CCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(=O)CCC(=O)N3CC4=CC=CC=C4C#CC5=CC=CC=C53
InChI
InChI=1S/C49H62N4O18/c54-42(11-12-43(55)51-37-40-7-2-1-5-38(40)9-10-39-6-3-4-8-41(39)51)50(19-23-64-27-31-68-35-33-66-29-25-62-21-17-48(60)70-52-44(56)13-14-45(52)57)20-24-65-28-32-69-36-34-67-30-26-63-22-18-49(61)71-53-46(58)15-16-47(53)59/h1-8H,11-37H2
InChIKey
LTXDZCUWVWVRMS-UHFFFAOYSA-N
Purity
0.95
Shipping
Ambient temperature
Storage
-20°C

DBCO-N-bis(PEG4-NHS ester), a versatile reagent with specific Click Chemistry properties, finds application in diverse bioconjugation processes. Here are four key applications:

Antibody-Drug Conjugates (ADCs): Leveraging DBCO-N-bis(PEG4-NHS ester), researchers synthesize ADCs by coupling antibodies with therapeutic drugs. These conjugates target cancer cell antigens, delivering cytotoxic agents directly to tumors. This precise targeting maximizes treatment efficacy while minimizing systemic toxicity, revolutionizing cancer therapy.

Surface Functionalization: Scientists utilize DBCO-N-bis(PEG4-NHS ester) to functionalize surfaces of nanoparticles, beads, or other materials, facilitating biomolecule attachment. This modification enables biosensing and bioseparation applications by accommodating proteins or peptides. The PEGylation effect enhances surface stability and biocompatibility, paving the way for advanced bioengineering endeavors.

Protein Labeling: Employing DBCO-N-bis(PEG4-NHS ester), researchers covalently attach fluorescent dyes or labels to proteins, enabling real-time tracking of protein interactions, localization, and dynamics in living cells. This labeling technique offers a reliable means to study protein functions and interactions at a molecular level, unraveling intricate biological processes.

Click Chemistry Reactions: Integral to Click Chemistry reactions, DBCO-N-bis(PEG4-NHS ester) facilitates specific and efficient bioorthogonal conjugations. This reagent reacts with azide-modified biomolecules, forming stable triazole linkages critical for developing novel biomaterials, engineering synthetic biology constructs, and crafting multifunctional therapeutic agents. Its widespread application drives innovation in bioconjugation science.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: DBCO-N-bis(PEG4-NHS ester)
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