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| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00952 | -- | $-- | Inquiry |
DBCO-CONH-S-S-NHS ester, a versatile bifunctional reagent, plays a pivotal role in the realms of bioconjugation and click chemistry. Delve into its diverse applications:
Bioconjugation: Serving as a precise biomolecule linker, DBCO-CONH-S-S-NHS ester emerges as a crucial tool in connecting antibodies or peptides to diverse surfaces or biomolecules. The DBCO moiety intricately engages azide groups in a bioorthogonal manner, facilitating swift and selective conjugation while upholding native biological processes. This method is indispensable for constructing targeted drug delivery systems and diagnostic assays.
Protein Labeling: Capitalizing on the NHS ester group, DBCO-CONH-S-S-NHS ester selectively interacts with primary amines on proteins, enabling efficient labeling and tracking both in vitro and in vivo. This capability is essential for probing protein dynamics, interactions, and localization within cellular milieus. Proteins can be embellished with fluorescent dyes or other tags, ushering in diverse imaging applications with profound implications for cutting-edge research initiatives.
Surface Functionalization: Harnessing the potency of DBCO-CONH-S-S-NHS ester, surfaces such as nanoparticles or biosensors can undergo functionalization by appending bioactive molecules. This strategic maneuvering facilitates the development of high-sensitivity biosensors adept at detecting specific biomolecules with extraordinary accuracy and specificity. The utilization of DBCO-CONH-S-S-NHS ester in surface functionalization also extends to bioseparation technologies, enabling the selective capture and isolation of target molecules.
Drug Development: Positioned as a game-changer in the realm of drug development, DBCO-CONH-S-S-NHS ester empowers the creation of prodrugs or conjugates that heighten therapeutic agent delivery and efficacy. Through the coupling of drugs with targeting moieties, researchers achieve precise site-specific drug delivery, consequently minimizing off-target effects and substantially enhancing therapeutic outcomes. This innovative approach not only bolsters the stability and bioavailability of pharmacologically active compounds but also unlocks new vistas for personalized medicine endeavors.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
