Name: DBCO-CONH-S-S-NHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Synonyms

DBCO-CONH-S-S-COONHS ester; Azadibenzocyclooctyne-S-S-NHS ester

IUPAC Name

Canonical SMILES

C1CC(=O)N(C1=O)OC(=O)CCSSCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42

InChI

InChI=1S/C28H27N3O6S2/c32-24(29-16-18-39-38-17-15-28(36)37-31-26(34)13-14-27(31)35)11-12-25(33)30-19-22-7-2-1-5-20(22)9-10-21-6-3-4-8-23(21)30/h1-8H,11-19H2,(H,29,32)

InChIKey

RPNGUSKTYYIUDE-UHFFFAOYSA-N

Solubility

10 mm in DMSO

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature, or blue ice upon request.

Storage

Store at 4 °C

DBCO-CONH-S-S-NHS ester, a versatile bifunctional reagent, plays a pivotal role in the realms of bioconjugation and click chemistry. Delve into its diverse applications:

Bioconjugation: Serving as a precise biomolecule linker, DBCO-CONH-S-S-NHS ester emerges as a crucial tool in connecting antibodies or peptides to diverse surfaces or biomolecules. The DBCO moiety intricately engages azide groups in a bioorthogonal manner, facilitating swift and selective conjugation while upholding native biological processes. This method is indispensable for constructing targeted drug delivery systems and diagnostic assays.

Protein Labeling: Capitalizing on the NHS ester group, DBCO-CONH-S-S-NHS ester selectively interacts with primary amines on proteins, enabling efficient labeling and tracking both in vitro and in vivo. This capability is essential for probing protein dynamics, interactions, and localization within cellular milieus. Proteins can be embellished with fluorescent dyes or other tags, ushering in diverse imaging applications with profound implications for cutting-edge research initiatives.

Surface Functionalization: Harnessing the potency of DBCO-CONH-S-S-NHS ester, surfaces such as nanoparticles or biosensors can undergo functionalization by appending bioactive molecules. This strategic maneuvering facilitates the development of high-sensitivity biosensors adept at detecting specific biomolecules with extraordinary accuracy and specificity. The utilization of DBCO-CONH-S-S-NHS ester in surface functionalization also extends to bioseparation technologies, enabling the selective capture and isolation of target molecules.

Drug Development: Positioned as a game-changer in the realm of drug development, DBCO-CONH-S-S-NHS ester empowers the creation of prodrugs or conjugates that heighten therapeutic agent delivery and efficacy. Through the coupling of drugs with targeting moieties, researchers achieve precise site-specific drug delivery, consequently minimizing off-target effects and substantially enhancing therapeutic outcomes. This innovative approach not only bolsters the stability and bioavailability of pharmacologically active compounds but also unlocks new vistas for personalized medicine endeavors.