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Boc-Ser(O-propargyl)-OH (DCHA) is a click chemistry reagent containing a propynyl group.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01876 | -- | $-- | Inquiry |
Boc-Ser(O-propargyl)-OH (DCHA), a versatile chemical compound utilized in diverse biochemical and pharmaceutical research settings, has a myriad of applications. Here are four key applications:
Peptide Synthesis: Integral to solid-phase peptide synthesis, Boc-Ser(O-propargyl)-OH (DCHA) functions as a protected serine derivative. The Boc group shields the amine functionality, while the O-propargyl group facilitates subsequent click chemistry reactions. This enables the integration of clickable serine into peptides for a range of bioconjugation investigations, adding layers of complexity to peptide assembly processes.
Click Chemistry: The alkyne moiety within Boc-Ser(O-propargyl)-OH (DCHA) positions it as a valuable reagent for diverse click chemistry applications. Coupled with azides, it enables the formation of stable triazole linkages crucial for labeling, imaging, and probing protein interactions within intricate biological systems. This synergy of chemical functionalities brings a dynamic and varied approach to studying molecular interactions.
Proteomics Research: In the realm of proteomics, Boc-Ser(O-propargyl)-OH (DCHA) finds utility in exploring post-translational modifications, particularly phosphorylation events. By incorporating this compound into synthetic peptides, researchers can generate phosphopeptide analogs, aiding in the examination of kinase activity and unraveling signal transduction pathways. This intricate molecular manipulation enhances our understanding of complex cellular signaling networks.
Drug Development: Within medicinal chemistry, Boc-Ser(O-propargyl)-OH (DCHA) emerges as a foundational unit for crafting novel therapeutic agents. The propargyl functionality enables the introduction of diverse functional groups that improve drug attributes, like bioavailability and metabolic stability. This strategic modification process is pivotal in designing potent and selectively targeted drug candidates, injecting a level of sophistication into drug discovery endeavors.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
