Name: Azido-PEG8-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

Azido-PEG8-acid;N3-PEG8-COOH; Azido-PEG8-C2-acid; Azido-PEG8-Acid; N3-PEG8-CH2CH2COOH; 1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid; 3,6,9,12,15,18,21,24-Octaoxaheptacosan-27-oic acid, 1-azido-; Azido-dPEG(R)8-acid

IUPAC Name

3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Canonical SMILES

C(COCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)O

InChI

InChI=1S/C19H37N3O10/c20-22-21-2-4-26-6-8-28-10-12-30-14-16-32-18-17-31-15-13-29-11-9-27-7-5-25-3-1-19(23)24/h1-18H2,(H,23,24)

InChIKey

URUGOEBULOZLBF-UHFFFAOYSA-N

Solubility

Soluble in DCM, DMF, DMSO, Water

Appearance

Pale Yellow Oily Matter

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature

Storage

Store at 2-8°C

Azido-PEG8-propionic acid, a versatile chemical compound featuring a polyethylene glycol (PEG) linker and an azide functional group, finds diverse applications in biochemical and pharmaceutical realms. Here are four key applications of Azido-PEG8-propionic acid presented with a high degree of perplexity and burstiness:

Bioorthogonal Chemistry: At the intersection of chemistry and biology, Azido-PEG8-propionic acid is a pivotal player in bioorthogonal chemistry. The azide group, with its unique reactivity towards alkyne groups via click chemistry, enables precise labeling and modifications in biological systems. This method allows for the specific attachment of probes and other molecules to biomolecules, facilitating the study of intricate biological processes in a minimally disruptive manner.

Drug Delivery Systems: With its PEG linker, Azido-PEG8-propionic acid enhances the solubility and stability of drugs, rendering it an indispensable component in drug delivery systems. When conjugated to therapeutic agents, it improves their pharmacokinetics and targeting capabilities. This advancement leads to more efficient and targeted treatments, reducing unwanted side effects and enhancing therapeutic outcomes.

Protein Modification and Conjugation: Azido-PEG8-propionic acid serves as a cornerstone for protein modification and conjugation. The azide group offers a means to attach PEG chains or other functional molecules to proteins, altering their properties such as solubility, stability, and immunogenicity. This capability is especially valuable in the realm of biopharmaceuticals and therapeutic proteins, facilitating the development of novel bioactive compounds.

Surface Functionalization: Embracing surface chemistry, Azido-PEG8-propionic acid demonstrates its utility in surface functionalization across nanoparticles, beads, and biosensors. By attaching Azido-PEG8-propionic acid to these surfaces, researchers create reactive sites for further conjugation with bioactive molecules. This customization empowers the generation of tailored surfaces for diverse biomedical and diagnostic applications, showcasing the versatility and adaptability of this compound.