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Ald-CH2-PEG5-azide is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00953 | -- | $-- | Inquiry |
Ald-CH2-PEG5-azide, a versatile bifunctional crosslinker essential in biochemical research and drug development, has diverse applications in various domains. Here are four key applications presented with high perplexity and burstiness:
Bioconjugation: Positioned as a cornerstone in molecular linking through click chemistry, Ald-CH2-PEG5-azide empowers researchers to forge connections between biomolecules by linking azide-functionalized molecules to aldehyde-containing targets. This intricate process fosters the synthesis of hybrid structures, such as proteins and nucleic acids, pivotal for the advancement of cutting-edge diagnostic tools and therapeutic agents.
Drug Delivery: Within the realm of drug development, Ald-CH2-PEG5-azide assumes a pivotal role in augmenting the solubility, stability, and biocompatibility of drug molecules. Through conjugation with polyethylene glycol (PEG) chains, therapeutic compounds undergo modification to enhance drug delivery efficiency, extending circulation time and enabling targeted delivery. This innovative paradigm yields optimized pharmacokinetic profiles and mitigates off-target effects, heralding a new era in drug delivery precision.
Surface Functionalization: Bridging material science and bioengineering realms, Ald-CH2-PEG5-azide serves as a linchpin in functionalizing nanoparticle surfaces, polymers, and an array of materials. By introducing azide groups onto surfaces, researchers seamlessly integrate a myriad of functional molecules, including targeting ligands and imaging agents. This foundational process underpins the development of cutting-edge materials for biomedical applications, such as biosensors and sophisticated drug delivery systems, propelling the frontier of bioengineering.
Proteomics: Playing a pivotal role in unraveling the intricacies of protein interactions and modifications, Ald-CH2-PEG5-azide facilitates crosslinking experiments that capture fleeting protein-protein interactions and delineate protein networks within cells.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
