Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-00004 | Colchicine | 64-86-8 |
| Colchicine, a toxic plant-derived alkaloid extracted from plants of the genus Colchicum, inhibits microtubule polymerization (IC50 = 3.2 μM). It inhibits the growth of MCF-7 human breast carcinoma cells and has anti-inflammatory activity. Colchicine can lower body temperature, inhibit the respiratory center, enhance the effect of sympathomimetic drugs, constrict blood vessels, and raise blood pressure. | Inquiry | |
| BADC-00040 | Dolastatin 10 | 110417-88-4 |
| Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibiting microtubule assembly. | Inquiry | |
| BADC-00086 | Mertansine | 139504-50-0 |
| Mertansine, the cytotoxic component in antibody-drug conjugates, is attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker or SMCC (4-(3-mercapto-2,5-dioxo-1 pyrrolidinylmethyl)-cylohexanecarboxylic acid) linkerto create an antibody-drug conjugate. It derives from a maytansine. | Inquiry | |
| BADC-00184 | Tubulysin A | 205304-86-5 |
| Tubulysin A is a novel antibiotic, which exhibits anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity. Tubulysins show very high cytotoxic activity against in vitro and in in vivo tumor models, especially against resistant tumor cell lines. Many representatives of these natural products are several orders of magnitude more potent than other available chemotherapeutics. | Inquiry | |
| BADC-00324 | MMAE | 474645-27-7 |
| Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity. | Inquiry | |
| BADC-00325 | Paclitaxel | 33069-62-4 |
| Paclitaxel is a compound with anti-tumor activity extracted from the Pacific yew tree Taxus brevifolia. Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. | Inquiry | |
| BADC-00339 | DM3 | 796073-54-6 |
| DM3 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates. | Inquiry | |
| BADC-00347 | DM4 | 796073-69-3 |
| DM4 is an anti-tubulin agent that inhibits cell division. DM4 can be used to prepare antibody-drug conjugates. DM4 binds to tubulin at the maytansine-binding site, disrupting microtubule assembly/disassembly dynamics and inhibiting mitosis. | Inquiry | |
| BADC-00357 | Ansamitocin P-3 | 66584-72-3 |
| It is produced by the strain of Nocardia sp. C-15003(N-1). It has the function of anti-tumor, anti-plant pathogenic fungi, skin fungi and protozoa, and has no antibacterial activity. | Inquiry | |
| BADC-00635 | MMAE-[d8] | 2070009-72-0 |
| MMAE-[d8] is a labelled analogue of MMAE, which is a potent mitotic inhibitor and a tubulin inhibitor. | Inquiry | |
| BADC-00687 | N-Me-L-Ala-maytansinol | 77668-69-0 |
| N-Me-L-Ala-maytansinol is a hydrophobic, cell permeable payload used in the preparation of antibody-drug conjugate (ADC). | Inquiry | |
| BADC-00087 | Maytansinoid DM4 | 799840-96-3 |
| DM4 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates. | Inquiry | |
| BADC-00190 | 7-Xylosyl-10-deacetyltaxol | 90332-63-1 |
| 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility. | Inquiry | |
| BADC-00717 | Boc-Val-Dil-Dap-Doe | 135383-62-9 |
| Boc-Val-Dil-Dap-Doe is a compound used to synthesize Dolastatin 10. Dolastatin 10 is a potent cytotoxin and involves inhibition of tubulin polymerization, tubulin-dependent guanosine triphosphate hydrolysis, and nucleotide exchange. | Inquiry | |
| BADC-00843 | D8-MMAD | |
| D8-MMAD is a deuterated form of MMAD, which is a microtubule disrupting agent. | Inquiry | |
| BADC-00844 | D8-MMAF hydrochloride | |
| D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent. | Inquiry |
