Amino-PEG2-t-butyl ester - CAS 756525-95-8

Amino-PEG2-t-butyl ester - CAS 756525-95-8 Catalog number: BADC-01152

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NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Amino-PEG2-t-butyl ester
CAS
756525-95-8
Catalog Number
BADC-01152
Molecular Formula
C11H23NO4
Molecular Weight
233.30
Amino-PEG2-t-butyl ester

Ordering Information

Catalog Number Size Price Quantity
BADC-01152 -- $--
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Description
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
Amino-PEG2-COOtBu; H2N-PEG2-CH2CH2COOtBu; tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
IUPAC Name
tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
Canonical SMILES
CC(C)(C)OC(=O)CCOCCOCCN
InChI
InChI=1S/C11H23NO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9,12H2,1-3H3
InChIKey
XIVHGTLMLORWEP-UHFFFAOYSA-N
Density
1.0±0.1 g/cm3
Solubility
10 mm in DMSO
Flash Point
103.3±18.7 °C
Index Of Refraction
1.450
LogP
0.48
PSA
70.78000
Vapor Pressure
0.0±0.7 mmHg at 25°C
Biological Activity
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] . ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]
Appearance
Colorless to light yellow clear liquid
Purity
> 98.0 %
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -5 ℃, keep in dry and avoid sunlight.
Pictograms
Corrosive; Irritant
Signal Word
Danger
Boiling Point
313.7±22.0 °C at 760 mmHg
Form
Liquid
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Amino-PEG2-t-butyl ester
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