Description
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
Amino-PEG2-COOtBu; H2N-PEG2-CH2CH2COOtBu; tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
IUPAC Name
tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
Canonical SMILES
CC(C)(C)OC(=O)CCOCCOCCN
InChI
InChI=1S/C11H23NO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9,12H2,1-3H3
InChIKey
XIVHGTLMLORWEP-UHFFFAOYSA-N
Flash Point
103.3±18.7 °C
Index Of Refraction
1.450
Vapor Pressure
0.0±0.7 mmHg at 25°C
Biological Activity
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] . ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]
Appearance
Colorless to light yellow clear liquid
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -5 ℃, keep in dry and avoid sunlight.
Pictograms
Corrosive; Irritant
Boiling Point
313.7±22.0 °C at 760 mmHg