NH2-PEG2-C2-Boc - CAS 756525-95-8

NH2-PEG2-C2-Boc - CAS 756525-95-8 Catalog number: BADC-01152

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NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

General Information

Category
ADCs Linker
Product Name
NH2-PEG2-C2-Boc
CAS
756525-95-8
Catalog Number
BADC-01152
Molecular Formula
C11H23NO4
Molecular Weight
233.30 g/mol

Chemical Structure

  • NH2-PEG2-C2-Boc
Purity
>98.0%
Appearance
Colorless to light yellow clear liquid
Synonyms
Tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate; Amino-PEG2-t-butyl ester
Solubility
10 mM in DMSO
Storage
Store at -5°C,keep in dry and avoid sunlight.
Shelf Life
-20℃ 3 years powder; -80℃ 2 years in solvent
Shipping
Room temperature, or blue ice upon request.
Canonical SMILES
CC(C)(C)OC(=O)CCOCCOCCN
InChI Key
XIVHGTLMLORWEP-UHFFFAOYSA-N
InChI
InChI=1S/C11H23NO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9,12H2,1-3H3
Form
Liquid
BiologicalActivity
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] . ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]

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Historical Records: Cardiotoxin | Sudemycin F1 | perfluorophenyl 2-(cyclooct-2-ynyloxy)acetate | 4-formylphenyl 3-iodo-4-methoxybenzoate | 5-hexynoic NHS ester | Argiotoxin | Alpha-Cobratoxin | DC4 | Nivalidine hydrochloride | Sudemycin C | NH2-PEG2-C2-Boc
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