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C-lock-G5-Dxd

  CAS No.:   Cat No.: BADC-01418 4.5  

C-lock-G5-Dxd is a thiol-reactive drug-linker conjugate used in the synthesis of antibody-drug conjugates (ADCs).

C-lock-G5-Dxd

Structure of

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ADC Cytotoxin with Linker
Molecular Formula
C48H48Br2FN11O12
Molecular Weight
1149.78

* For research and manufacturing use only. We do not sell to patients.

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IUPAC Name
2,3-bis(bromomethyl)-N-(1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1,6,9,12,15,18-hexaoxo-3-oxa-5,8,11,14,17-pentaazanonadecan-19-yl)quinoxaline-6-carboxamide
InChI
InChI=1S/C48H48Br2FN11O12/c1-3-48(72)27-9-35-44-25(18-62(35)46(70)26(27)19-74-47(48)71)43-30(7-5-24-22(2)28(51)10-32(61-44)42(24)43)60-41(68)20-73-21-57-40(67)16-55-38(65)14-53-36(63)13-52-37(64)15-54-39(66)17-56-45(69)23-4-6-29-31(8-23)59-34(12-50)33(11-49)58-29/h4,6,8-10,30,72H,3,5,7,11-21H2,1-2H3,(H,52,64)(H,53,63)(H,54,66)(H,55,65)(H,56,69)(H,57,67)(H,60,68)/t30-,48-/m0/s1
InChIKey
POZQMHNRWNUTOC-LBWMNDTPSA-N

C-lock-G5-Dxd, a state-of-the-art molecular tool meticulously crafted for precise and targeted delivery of therapeutic agents, boasts a myriad of innovative applications. Here are four key applications of C-lock-G5-Dxd:

Targeted Cancer Therapy: Harnessing the capabilities of C-lock-G5-Dxd, researchers can revolutionize cancer treatment by directing chemotherapeutic agents exclusively to malignant cells, thereby minimizing collateral damage to healthy tissues. This focused approach not only amplifies the effectiveness of cancer therapy by concentrating the therapeutic payload at the tumor site but also reduces the overall dosage required, consequently mitigating systemic toxicity.

Gene Delivery: In the realm of gene therapy, C-lock-G5-Dxd emerges as a pivotal tool for the precise delivery of genetic material to specific cell populations. Facilitating the introduction of genes encoding therapeutic proteins or rectifying faulty genetic sequences, this molecular marvel holds immense promise for addressing genetic disorders. Its pinpoint targeting prowess ensures that genetic cargo reaches the designated cells without encroaching on non-targeted cellular territories.

Neurological Research: Delving into the complexities of neurological ailments, C-lock-G5-Dxd offers a cutting-edge solution for surmounting the blood-brain barrier, a formidable obstacle in treating brain-related disorders. Researchers can utilize this tool to transport neuroprotective compounds, growth factors, or genetic material to precise brain regions. Such applications play a pivotal role in advancing therapeutic strategies for debilitating conditions like Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.

Personalized Medicine: Pioneering the frontier of personalized medicine, C-lock-G5-Dxd enables tailored therapeutics based on an individual’s unique genetic blueprint. By customizing treatment regimens to align with a patient’s distinct biological characteristics, this molecular tool facilitates highly specific and targeted interventions. Such personalized delivery of drugs and genetic material not only enhances therapeutic efficacy but also reduces the likelihood of adverse reactions, ushering in a new era of precision medicine.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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