Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-01345 | MC-Val-Ala-SG3199 | |
| MC-Val-Ala-SG3199 is a potent cytotoxic compound. It is a potent, selective, irreversible inhibitor with a high reputation in the biomedical field. Its most important significance is in the fight against cancer, especially those that are refractory to traditional treatments. This compound triggers cell death by specifically targeting an enzyme that plays a key role in the ominous expansion and proliferation of tumors. | Inquiry | |
| BADC-01380 | SG2057 | 260417-62-7 |
| SG2057 is a pentyldioxy linked PBD dimer which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts, and also mono-adducts depending on sequence. SG2057 has multilog differential in vitro cytotoxicity against a panel of human tumour cell lines with a mean GI(50) of 212 pM. The agent is highly efficient at producing DNA interstrand cross-links in cells which form rapidly and persist over a 48h period. Cures were obtained in a LOX-IMVI melanoma model following a single administration and dose-dependent activity, including regression responses, observed in SKOV-3 ovarian and HL-60 promyelocytic leukemia models following repeat dose schedules. In the advanced stage LS174T model, SG2057 administered either as a single dose, or in two repeat dose schedules, was superior to irinotecan. SG2057 is therefore a highly active antitumor agent, with more potent in vitro activity and superior in vivo activity to SG2000. | Inquiry | |
| BADC-00015 | MC-Val-Ala-PBD | 1342820-51-2 |
| MC-Val-Ala-PBD is a protective group conjugated PBD, PBD bind in the minor groove of DNA. | Inquiry | |
| BADC-00340 | PBD dimer | 1222490-34-7 |
| PBD dimer is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. | Inquiry | |
| BADC-00670 | Mal-PEG4-VA-PBD | 2259318-50-6 |
| Mal-PEG4-VA-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via Mal-PEG4-VA. | Inquiry | |
| BADC-00738 | MA-PEG4-VA-PBD | 1342820-68-1 |
| MA-PEG4-VA-PBD is a drug-linker conjugate for ADC by using PBD (Pyrrolobenzodiazepine dimers, a potent antitumor antibiotic), linked via MA-PEG4-VA. | Inquiry | |
| BADC-00826 | Aniline-MPB-amino-C3-PBD | 2412923-79-4 |
| Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised of the non-alkylating group. It is a sequence-selective DNA minor-groove binding agent. | Inquiry | |
| BADC-00827 | Py-MPB-amino-C3-PBD | 2412924-07-1 |
| Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group, with antimicrobial activity. | Inquiry | |
| BADC-00851 | Tesirine | 1595275-62-9 |
| Tesirine (SG3249) is a drug-linker conjugates for ADC which is used in the treatment of several cancers. PBD Dimer is a DNA alkylating which inhibits DNA replication. | Inquiry | |
| BADC-01353 | SG3199 | 1595275-71-0 |
| SG3199 is a cytotoxic DNA minor groove interchain cross-linked PDB dimer. SG3199 is a component of ADC payload Tesirine (SG3249). | Inquiry | |
| BADC-01486 | Dimethyl-SGD-1882 | |
| Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylator (DNA alkylator), which can be used as the toxin moiety of antibody drug conjugate (ADC). PBD Dimer is a DNA alkylating agent that inhibits DNA replication. | Inquiry |
