Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-00337 | Seco-Duocarmycin TM | 1142188-60-0 |
| Seco-Duocarmycin TM is a highly potent ADC payload causing DNA alkylation and tumor cell death. Its incorporation as an ADC cytotoxin enhances antibody-drug conjugate specificity and efficacy, making it ideal for precision oncology applications. | Inquiry | |
| BADC-00341 | Seco-Duocarmycin SA | 152785-82-5 |
| Seco-Duocarmycin SA is a potent ADC cytotoxin payload with alkylating activity that selectively targets DNA in tumor cells. It enhances antibody-drug conjugate efficacy through precise cytotoxic payload delivery, aiding in targeted cancer therapies with improved safety profiles. | Inquiry | |
| BADC-01400 | Seco-DUBA | 1227961-59-2 |
| seco-DUBA hydrochloride is a cell-permeable pro-drug that is cleaved into the active toxin (DUBA) in intracellular lysosomes by proteases, after internalization. The payload then alkylates the DNA, causing DNA damage and cell death. | Inquiry | |
| BADC-00223 | Duocarmycin A | 118292-34-5 |
| It is produced by the strain of (Pyridamycin) Streptomyces sp. DO-88. It has strong antibacterial and antitumor activity. It can inhibit gram-positive bacteria such as Staphylococcus aureus and Streptococcus faecalis (MIC is less than 0.01 μg/mL), it can also inhibit klebsiella pneumoniae (MIC is 0.032 μg/mL), other bacteria and yeast (MIC is 1-10 μg/mL). | Inquiry | |
| BADC-00342 | Seco-Duocarmycin MA | 1613286-57-9 |
| Seco-Duocarmycin MA acts as a powerful ADC payload that covalently binds DNA, inducing apoptosis in malignant cells. As an ADC cytotoxin, it improves targeted drug delivery in antibody-drug conjugates, supporting innovative cancer treatment strategies. | Inquiry | |
| BADC-00605 | Duocarmycin TM | 157922-77-5 |
| Duocarmycin TM is an exceptionally potent antitumor antibiotic. Duocarmycin TM is a DNA alkylator. | Inquiry | |
| BADC-00633 | MC-Val-Cit-PAB-duocarmycin | 2055896-98-3 |
| MC-Val-Cit-PAB-duocarmycin is a drug-linker conjugate for ADC with potent antitumor activity by using duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB. | Inquiry | |
| BADC-00680 | DC1-SMe | 501666-85-9 |
| DC1-Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. | Inquiry | |
| BADC-00681 | DC0-NH2 | 615538-51-7 |
| DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component. | Inquiry | |
| BADC-00865 | Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA | 2259318-49-3 |
| Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is a drug-linker conjugate for ADC by using the antitumor antibiotic, Duocarmycin SA, linked via Mal-PEG4-VC-PAB-DMEA-Seco. | Inquiry | |
| BADC-00871 | Fmoc-Val-Cit-PAB-Duocarmycin TM | |
| Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate for ADC by using the antitumor antibiotic, Duocarmycin TM, linked via Fmoc-Val-Cit-PAB. | Inquiry | |
| BADC-01367 | Seco-DUBA hydrochloride | 1795733-93-5 |
| Seco-DUBA hydrochloride is a DNA-alkylating ADC payload that selectively induces tumor cell death. As an ADC cytotoxin, it improves antibody-drug conjugate performance in targeted chemotherapy with controlled toxicity. | Inquiry | |
| BADC-01385 | DC10SMe | |
| DC10SMe is a DNA alkylating agent useful in the synthesis of antibody drug conjugates (ADCs). DC10SMe has IC50 values of 15 pM, 12 pM and 12 pM against Ramos, Namalwa and HL60/s cancer cells, respectively. | Inquiry | |
| BADC-01465 | MB-VC-MGBA | 932744-62-2 |
| MB-VC-MGBA is a part of antibody drug conjugates, which is formed by linking DNA alkylating agent MGBA and ADC linker MB-VC. | Inquiry | |
| BADC-01466 | Desmethyl Vc-seco-DUBA | |
| Desmethyl Vc-seco-DUBA is an innovative biomedical product used in the treatment of various diseases. It exhibits potent anti-inflammatory properties, making it effective in managing chronic inflammation associated with autoimmune disorders. Its precise mechanism of action involves specifically targeting the overactive immune response and modulating inflammatory pathways. By alleviating inflammation, Desmethyl Vc-seco-DUBA offers promising therapeutic potential in conditions such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. | Inquiry |
