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As the chemical derivatives of Maytansine, Maytansinoids are tubulin inhibitors with the strongest known activities. It has strong inhibitory activities against various tumor cells and solid tumor systems. Since the greater toxic side effects when directly used in clinical treatment, Maytansinoids are commonly used as potent cytotoxic payloads in antibody-drug conjugates (ADCs). In the ADCs format, these potent Maytansinoids could be targeted to specific (diseased) cell types, thereby expanding their therapeutic window. Since that time, many other Maytansinoids have been developed as antibody payloads.
