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Cleavable Linker
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Cleavable Linker

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Catalog Product Name CAS Number
BADC-00884 m-PEG8-Ms 1059588-19-0
m-PEG8-Ms is a mesylate-activated PEG linker used in antibody-drug conjugates for efficient nucleophilic substitution reactions. Its PEG8 spacer increases hydrophilicity and solubility of payloads, improving bioconjugate stability and pharmacokinetic profiles in targeted therapies. Inquiry
BADC-00887 t-Boc-N-amido-PEG4-bromide 1076199-21-7
t-Boc-N-amido-PEG3-bromide is a PEG linker containing a bromide group and a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine. Inquiry
BADC-00890 mPEG4-bromide 110429-45-3
mPEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. Inquiry
BADC-00891 (2-pyridyldithio)-PEG1-hydrazine 111625-28-6
(2-pyridyldithio)-PEG1-hydrazine is a cleavable ADC linker featuring pyridyl disulfide and hydrazine groups. It facilitates thiol-reactive conjugation and hydrazone chemistry for pH-sensitive payload release in ADC development. Inquiry
BADC-00892 N-(Iodoacetamido)-Doxorubicin 114390-30-6
N-(Iodoacetamido)-Doxorubicin is an ADC payload-linker conjugate featuring iodoacetamide for cysteine-specific attachment, enabling targeted delivery and controlled release in antibody-drug conjugates. Keywords: ADC linker, iodoacetamide linker, doxorubicin payload, cysteine conjugation, targeted therapy. Inquiry
BADC-00894 SPDB 115088-06-7
SPDB (N-Succinimidyl 4-(2-pyridyldithio)butanoate) is a disulfide-containing ADC linker used for reversible thiol conjugation. It supports cleavable drug-antibody coupling, allowing selective release under reductive intracellular conditions, commonly employed in ADC development. Inquiry
BADC-00895 Fmoc-N-amido-PEG9-acid 1191064-81-9
Fmoc-N-amido-PEG9-acid is a high-performance ADC linker featuring a PEG9 spacer that enhances solubility and flexibility. It facilitates efficient and stable drug-antibody conjugation, making it ideal for targeted cancer therapy development. Inquiry
BADC-00900 Azido-PEG8-NHS ester 1204834-00-3
Azido-PEG8-NHS ester enables bioorthogonal click chemistry in ADC linker design, improving conjugation efficiency and stability for targeted antibody-drug conjugates with enhanced pharmacokinetics. Inquiry
BADC-00903 NHS-SS-biotin 122266-55-1
NHS-SS-biotin is a cleavable ADC linker combining NHS ester for amine coupling and disulfide-linked biotin for affinity tagging. Widely used in ADC bioconjugation and targeted drug delivery studies. Inquiry
BADC-00908 DBCO-amine 1255942-06-3
DBCO-amine is a core ADC linker building block with a dibenzocyclooctyne group for copper-free click conjugation, enabling efficient and site-specific antibody-payload attachment in targeted therapies. Inquiry
BADC-00909 DBCO-NH-PEG4-amine 1255942-08-5
DBCO-NH-PEG4-amine is a versatile ADC linker featuring a dibenzocyclooctyne group for copper-free click chemistry. Ideal for antibody-drug conjugate development, it enables efficient bioconjugation via strain-promoted azide-alkyne cycloaddition (SPAAC), enhancing stability and hydrophilicity in targeted drug delivery systems. Inquiry
BADC-00910 DBCO-NHCO-PEG4-NH-Boc 1255942-12-1
DBCO-NHCO-PEG4-NH-Boc is a protected amine-containing ADC linker enabling future payload conjugation via SPAAC. Its PEG4 spacer enhances solubility, while the Boc-protected amine allows orthogonal synthetic strategies in ADC and bioconjugate design. Inquiry
BADC-00912 t-Boc-N-amido-PEG1-propionic acid 1260092-44-1
t-Boc-N-amido-PEG1-propionic acid is a cleavable (1-unit PEG) ADC linker, as well as a PEG- and alkyl/ether-based PROTAC linker that can be used to synthesize antibody-drug conjugates (ADCs) or PROTACs. Inquiry
BADC-00913 Bis-PEG9-acid 1268488-70-5
Bis-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-PEG9-acid is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Inquiry
BADC-00916 t-Boc-N-amido-PEG7-alcohol 1292268-13-3
t-Boc-N-amido-PEG7-alcohol is a protected amine-functionalized PEG linker designed for ADC intermediate synthesis. The PEG7 chain improves solubility and pharmacokinetics, making it suitable for multistep conjugation strategies. Inquiry
BADC-00917 Amino-PEG10-alcohol 129449-09-8
Amino-PEG10-alcohol is a bifunctional PEG linker featuring both amine and alcohol groups, used in ADC linker chemistry for flexible conjugation strategies. Its extended PEG10 spacer increases solubility and minimizes immunogenicity of antibody-drug conjugates. Inquiry
BADC-00920 m-PEG4-Ms 130955-37-2
m-PEG4-Ms provides a shorter mesyl-activated PEG linker option for ADC construction, enhancing payload solubility and reactivity. It enables effective conjugation to nucleophiles, supporting flexible linker design in antibody-drug conjugation and controlled drug release systems. Inquiry
BADC-00921 m-PEG5-Ms 130955-38-3
m-PEG5-Ms is a mesylated monofunctional PEG linker used in ADC construction to facilitate nucleophilic substitution. The PEG5 spacer boosts solubility and stability of conjugates, making it suitable for drug-linker modification and enhancing targeted therapeutic delivery. Inquiry
BADC-00924 Bis-PEG7-NHS ester 1334170-02-3
Bis-PEG7-NHS ester provides a long-chain homobifunctional PEG linker for bioconjugation via NHS ester chemistry. Ideal for constructing highly soluble, flexible ADC linkers with improved drug delivery performance. Inquiry
BADC-00929 Fmoc-D-Val-Cit-PAB 1350456-65-3
Fmoc-D-Val-Cit-PAB is a cleavable ADC linker with Val-Cit dipeptide and PAB spacer, facilitating enzymatic drug release and site-specific antibody conjugation in targeted cancer therapy. Inquiry
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