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Cleavable Linker
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Cleavable Linker

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Catalog Product Name CAS Number
BADC-00989 2-Aminoethyl-mono-amide-DOTA-tris(t-Bu ester) 173308-19-5
2-Aminoethyl-mono-amide-DOTA-tris(t-Bu ester) is a protected chelator for radiolabeled ADCs. It facilitates stable coordination of radionuclides while providing amine functionality for antibody conjugation. Widely used in theranostic applications combining imaging and targeted drug delivery. Inquiry
BADC-00990 Amino-Tri-(carboxyethoxymethyl)-methane 174362-95-9
Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Inquiry
BADC-00993 TCO-PEG4-DBCO 1801863-88-6
TCO-PEG4-DBCO is a dual-functional ADC linker combining trans-cyclooctene and DBCO groups for click chemistry and bioorthogonal reactions. Used in pretargeting strategies, it supports rapid, selective antibody-payload assembly in drug conjugate synthesis. Inquiry
BADC-00995 PC Alkyne-PEG4-NHS ester 1802907-98-7
PC Alkyne-PEG4-NHS ester is a cleavable ADC linker combining alkyne click chemistry and NHS ester for amine conjugation, improving payload attachment and release in antibody-drug conjugates. Inquiry
BADC-00997 Propargyl-PEG1-SS-PEG1-acid 1807503-85-0
Propargyl-PEG1-SS-PEG1-acid is a cleavable disulfide ADC linker with alkyne and carboxylic acid groups, facilitating copper-catalyzed click chemistry and amine coupling in ADC synthesis. Inquiry
BADC-00998 THP-SS-PEG1-Boc 1807503-88-3
THP-SS-PEG1-Boc is a disulfide-containing, Boc-protected PEG linker used in ADCs to enable redox-sensitive drug release and stable antibody conjugation via bioorthogonal chemistry. Inquiry
BADC-00999 THP-SS-PEG1-Tos 1807512-37-3
THP-SS-PEG1-Tos is a tosylate-activated, disulfide PEG linker facilitating cleavable conjugation in antibody-drug conjugates, enhancing payload release and linker stability under physiological conditions. Inquiry
BADC-01000 Azidoethyl-SS-ethylamine 1807512-40-8
Azidoethyl-SS-ethylamine is a bifunctional ADC linker featuring azide and amine groups with a cleavable disulfide bond, supporting site-specific conjugation and controlled intracellular drug release. Inquiry
BADC-01001 Bromoacetamido-PEG4-acid 1807518-67-7
Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Inquiry
BADC-01002 Mal-PEG1-NHS ester 1807518-72-4
Mal-PEG1-NHS ester is a heterobifunctional linker with maleimide and NHS ester groups, enabling selective thiol-to-amine conjugation in ADC synthesis. Its short PEG1 spacer increases aqueous solubility and enhances bioconjugation efficiency for targeted drug delivery. Inquiry
BADC-01003 Fmoc-NMe-PEG3-acid 1807518-77-9
Fmoc-NMe-PEG3-acid is a PEG linker containing a Fmoc-protected amine and a terminal carboxylic acid. The Fmoc group can be deprotected under the basic conditions to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. Inquiry
BADC-01004 Propargyl-PEG1-SS-PEG1-C2-Boc 1807518-78-0
Propargyl-PEG1-SS-PEG1-C2-Boc is a disulfide-containing cleavable ADC linker with alkyne and Boc-protected amine groups. Ideal for redox-sensitive drug release in targeted therapeutics. Inquiry
BADC-01005 2-Hydroxyethyl disulfide mono-tosylate 1807530-16-0
2-Hydroxyethyl disulfide mono-tosylate is a cleavable disulfide ADC linker precursor facilitating thiol-reactive conjugation. Widely applied in antibody-drug conjugate chemistry for controlled payload release and linker stability. Inquiry
BADC-01007 Acid-PEG2-SS-PEG2-acid 1807539-10-1
Acid-PEG2-SS-PEG2-acid is a cleavable ADC linker with PEG spacers and disulfide bonds, featuring terminal acid groups for flexible conjugation. Improves solubility and enables controlled drug release in antibody-drug conjugates. Inquiry
BADC-01008 Propargyl-PEG1-SS-PEG1-PFP ester 1817735-30-0
Propargyl-PEG1-SS-PEG1-PFP ester is a bifunctional cleavable ADC linker with alkyne and pentafluorophenyl ester groups, enabling stable payload attachment and copper-catalyzed click conjugation. Inquiry
BADC-01010 DBCO-PEG4-amine 1840886-10-3
DBCO-PEG4-amine is a core ADC linker with DBCO for strain-promoted azide-alkyne cycloaddition and a reactive amine for further functionalization, supporting site-specific antibody conjugation. Inquiry
BADC-01011 mPEG6-amine 184357-46-8
mPEG6-amine is a mid-length PEG linker offering terminal amine reactivity, commonly used in antibody-drug conjugation. Its PEG6 spacer enhances flexibility, solubility, and stability, contributing to improved pharmacokinetics of ADC therapeutics. Inquiry
BADC-01013 Azido-PEG3-maleimide 1858264-36-4
Azido-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-maleimide is also a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Inquiry
BADC-01016 PC Biotin-PEG3-alkyne 1869922-24-6
PC Biotin-PEG3-alkyne is a biotinylated ADC linker with alkyne functionality, enabling click chemistry conjugation and affinity purification for enhanced antibody-drug conjugate development. Inquiry
BADC-01017 DBCO-PEG5-acid 1870899-46-9
DBCO-PEG5-acid is a DBCO-terminated PEG linker ideal for azide-reactive SPAAC conjugation in antibody-drug conjugates. It supports site-specific, copper-free click chemistry, enhancing payload attachment and maintaining ADC stability in physiological environments. Inquiry
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