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Cleavable Linker
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Cleavable Linker

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Catalog Product Name CAS Number
BADC-01118 Azidoethyl-SS-ethylazide 352305-38-5
Azidoethyl-SS-ethylazide is a bifunctional cleavable ADC linker featuring azide and disulfide groups, enabling bioorthogonal conjugation and redox-sensitive drug release in targeted therapeutics. Inquiry
BADC-01119 Fmoc-Gly-Gly-OH 35665-38-4
Fmoc-Gly-Gly-OH is a dipeptide linker component commonly used in cleavable ADC linker systems. Its small, flexible structure enables lysosomal enzyme-triggered cleavage, making it ideal for use in cytotoxic drug release applications within antibody-drug conjugates and other bioconjugates. Inquiry
BADC-01121 Amino-PEG6-alcohol 39160-70-8
Amino-PEG6-alcohol is a bifunctional PEG linker with terminal amine and alcohol groups, commonly used in ADC synthesis to improve solubility and flexibility. Its PEG6 spacer aids in stable conjugation and enhances pharmacokinetics of antibody-drug conjugates. Inquiry
BADC-01124 Fmoc-N-amido-PEG4-acetic acid 437655-95-3
Fmoc-N-amido-PEG4-acetic acid is a PEG linker intermediate with an Fmoc protecting group, used for stepwise ADC linker synthesis. The PEG4 spacer improves hydrophilicity and flexibility, aiding in controlled payload conjugation and antibody modification. Inquiry
BADC-01126 m-PEG7-Ms 477775-57-8
m-PEG7-Ms is a mesylated monofunctional PEG linker offering high solubility and reactivity. Commonly used in ADCs, it serves as a spacer to improve pharmacokinetics of hydrophobic drugs. The mesyl group enables efficient substitution with amines, thiols, or other nucleophiles during linker modification. Inquiry
BADC-01127 Boc-Cystamine 485800-26-8
Boc-Cystamine is a protected disulfide-containing ADC linker building block, enabling redox-sensitive payload attachment and site-specific antibody conjugation. Inquiry
BADC-01128 Boc-NH-ethyl-SS-propionic acid 485800-27-9
Boc-NH-ethyl-SS-propionic acid is a cleavable ADC linker with Boc protection and disulfide bond, facilitating site-specific conjugation and controlled drug release in antibody-drug conjugates. Inquiry
BADC-01131 Maleimido-tri(ethylene glycol)-propionic acid 518044-40-1
Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation. Inquiry
BADC-01136 Br-PEG4-COOtBu 564476-32-0
Br-PEG4-COOtBu is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. Inquiry
BADC-01137 Hydroxy-PEG3-SS-PEG3-alcohol 5662-81-7
Hydroxy-PEG3-SS-PEG3-alcohol offers a cleavable PEGylated ADC linker with disulfide bonds and hydroxyl groups. This facilitates enhanced solubility and controlled drug release in antibody-drug conjugates, optimizing delivery in oncology applications. Inquiry
BADC-01138 5-Maleimidovaleric acid 57078-99-6
5-Maleimidovaleric acid is a thiol-reactive ADC linker commonly used to attach payloads to antibodies through maleimide–cysteine coupling. It offers excellent solubility and stability, supporting targeted drug delivery and selective release in tumor microenvironments. Inquiry
BADC-01139 N-Succinimidyl 3-(Bromoacetamido)propionate 57159-62-3
N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Inquiry
BADC-01141 (2-pyridyldithio)-PEG4 acid 581065-93-2
(2-pyridyldithio)-PEG4 acid is a cleavable ADC linker with pyridyldithiol for thiol-reactive conjugation and PEG spacer for solubility. Widely used in targeted antibody-drug conjugate design to improve payload stability and release. Inquiry
BADC-01142 Fmoc-N-amido-PEG5-acetic acid 635287-26-2
Fmoc-N-amido-PEG5-acetic acid offers a longer PEG5 spacer with an Fmoc group, supporting advanced ADC linker synthesis. Its enhanced hydrophilicity and protecting group allow precise stepwise conjugation in antibody-drug conjugate production. Inquiry
BADC-01143 DMAC-PDB 663599-04-0
DMAC-PDB is a potent ADC linker designed for stable payload attachment with optimized release profiles. It supports precise bioconjugation strategies in antibody-drug conjugates for enhanced therapeutic efficacy. Inquiry
BADC-01144 Amino-PEG4-propionic acid 663921-15-1
Amino-PEG4-propionic acid is a medium-length PEG linker intermediate designed to improve antibody solubility and conjugation stability in ADCs. It enhances drug loading efficiency and supports controlled payload release for targeted therapies. Inquiry
BADC-01146 N-Butanoyl-L-homoserine lactone 67605-85-0
N-Butanoyl-L-homoserine lactone is a signaling-mimetic compound used in linker design for controlled release in ADCs. Its lactone ring structure introduces enzymatically cleavable characteristics, allowing selective payload release in tumor microenvironments and enhancing therapeutic specificity. Inquiry
BADC-01148 Bis-Tos-(2-hydroxyethyl disulfide) 69981-39-1
Bis-Tos-(2-hydroxyethyl disulfide) is a bifunctional disulfide ADC linker with tosylate leaving groups, enabling cleavable conjugation and controlled intracellular drug release in targeted antibody therapeutics. Inquiry
BADC-01149 mPEG3-amine 74654-07-2
mPEG3-amine is a short-chain, amine-functionalized PEG linker offering compact size for ADC applications. Enhances solubility and stability of antibody-drug complexes while minimizing steric hindrance. Inquiry
BADC-01151 t-Boc-N-amido-PEG4-propionic acid 756525-91-4
Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Inquiry
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