Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-00004 | Colchicine | 64-86-8 |
| Colchicine, a toxic plant-derived alkaloid extracted from plants of the genus Colchicum, inhibits microtubule polymerization (IC50 = 3.2 μM). It inhibits the growth of MCF-7 human breast carcinoma cells and has anti-inflammatory activity. Colchicine can lower body temperature, inhibit the respiratory center, enhance the effect of sympathomimetic drugs, constrict blood vessels, and raise blood pressure. | Inquiry | |
| BADC-00184 | Tubulysin A | 205304-86-5 |
| Tubulysin A is a novel antibiotic, which exhibits anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity. Tubulysins show very high cytotoxic activity against in vitro and in in vivo tumor models, especially against resistant tumor cell lines. Many representatives of these natural products are several orders of magnitude more potent than other available chemotherapeutics. | Inquiry | |
| BADC-00325 | Paclitaxel | 33069-62-4 |
| Paclitaxel is a compound with anti-tumor activity extracted from the Pacific yew tree Taxus brevifolia. Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. | Inquiry | |
| BADC-00190 | 7-Xylosyl-10-deacetyltaxol | 90332-63-1 |
| 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility. | Inquiry | |
| BADC-00817 | Muscotoxin A | 1653999-47-3 |
| Muscotoxin A is an ADC cytotoxin. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death. | Inquiry | |
| BADC-00818 | Vipivotide tetraxetan | 1702967-37-0 |
| Vipivotide tetraxetan is a high potent inhibitor of prostate-specific membrane antigen (PSMA)(Ki of 0.37 nM). | Inquiry | |
| BADC-00823 | ε-Amanitin | 21705-02-2 |
| ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II. | Inquiry | |
| BADC-00831 | Telomestatin | 265114-54-3 |
| Telomostatin, originally isolated from the bacteria Streptomyces anulatus, is a potent and specific telomerase inhibitor that acts only on human telomere sequences and does not affect DNA polymerases or reverse transcriptases. Telomostatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. | Inquiry | |
| BADC-00845 | Isofistularin-3 | |
| Isofistularin-3 is a direct, DNA-competitive DNMT1 inhibitor, with an IC50 of 13.5 μM. Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin. | Inquiry | |
| BADC-00853 | MC-VC-PABC-DNA31 | 1639352-03-6 |
| MC-VC-PABC-DNA31 is a drug-linker conjugate for ADC with potent antitumor activity by using DNA31 (a potent RNA polymerase inhibitor), linked via the ADC linker MC-VC-PABC. | Inquiry | |
| BADC-00857 | MC-Val-Cit-PAB-vinblastine | 2055896-92-7 |
| MC-Val-Cit-PAB-vinblastine is a drug-linker conjugate for ADC with potent antitumor activity by using vinblastine (an microtubule protein inhibitor), linked via the ADC linker MC-Val-Cit-PAB. | Inquiry | |
| BADC-00858 | MC-Val-Cit-PAB-rifabutin | 2055900-34-8 |
| MC-Val-Cit-PAB-rifabutin is a drug-linker conjugate for ADC with potent antitumor activity by using rifabutin (an DNA-dependent RNA polymerase inhibitor), linked via the ADC linker MC-Val-Cit-PAB. | Inquiry | |
| BADC-00859 | DGN549-C | 2058075-34-4 |
| DGN549-C consists a cleavable ADC linker valine-alanine (va) and PBD dimer. DGN549 is a novel DNA-alkylating cytotoxic payload and can be used in the synthesis of antibody-drug conjugates (ADCs). | Inquiry | |
| BADC-00860 | Mal-PEG2-VCP-Eribulin | 2130869-18-8 |
| Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin. Eribulin is a mechanistically unique microtubule inhibitor for cancer. Mal-PEG2-VCP-Eribulin is an Eribulin-based drug for antibody conjugates. | Inquiry | |
| BADC-00869 | AcLysValCit-PABC-DMAE-SW-163D | 2411007-69-5 |
| AcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker. | Inquiry | |
| BADC-01369 | Hemiasterlin | 157207-90-4 |
| Hemiasterlin, a highly cytotoxic marine natural product, is used in a targeted therapeutic which was demonstrated by incorporation as a payload in an antibody-drug conjugate (ADC). It acts by inducing mitotic arrest and abnormal spindle formation. | Inquiry | |
| BADC-01370 | Azonafide-PEABA | |
| Azonafide-PEABA is a cytotoxic drug. | Inquiry | |
| BADC-01374 | Hemiasterlin derivative-1 | 1887046-60-7 |
| Hemiasterlin derivative-1 is a derivative of hemiasterlin. Hemiasterlin inhibits cell growth by depolymerizing existing microtubules and inhibiting microtubule assembly. | Inquiry | |
| BADC-01381 | Taltobulin hydrochloride | |
| Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic tripeptide cysteine analog, Taltobulin is a potent antimicrotubule that circumvents P-glycoprotein-mediated drug resistance in vitro and in vivo sex. Taltobulin hydrochloride inhibits purified tubulin polymerization, disrupts microtubule organization in cells, and induces mitotic arrest and apoptosis. | Inquiry | |
| BADC-01470 | MC-Val-Cit-PAB-dimethylDNA31 | 1639352-06-9 |
| MC-Val-Cit-PAB-dimethylDNA31 has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Val-Cit-PAB-dimethylDNA31 is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders. | Inquiry |
