Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-01393 | Irinotecan EP Impurity E (SN-38) | 86639-52-3 |
| An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. It inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. | Inquiry | |
| BADC-01397 | Chimmitecan | 185425-25-6 |
| Chimmitecan is a potent topoisomerase I inhibitor. Chimmitecan is also an active metabolite of simmitecan. Chimmitecan displays outstanding activity in vitro and in vivo. The substitution at the 9-position benefits chimmitecan a salient anti-MDR activity, stability in human serum albumin, improved solubility, and oral availability, which might favorably promise its therapeutic potential in clinical settings. | Inquiry | |
| BADC-01394 | DXD | 1599440-33-1 |
| DXD, an Exatecan derivative for ADC, is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 μM. It can be used as a payload for antibody-conjugated drug ADCs targeting HER2. | Inquiry | |
| BADC-00666 | MAC glucuronide phenol-linked SN-38 | 2246380-69-6 |
| MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively. | Inquiry | |
| BADC-00667 | MAC glucuronide α-hydroxy lactone-linked SN-38 | 2246380-70-9 |
| MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively. | Inquiry | |
| BADC-00847 | CL2-SN-38 | 1036969-20-6 |
| CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 and a maleimidocaproyl linker. | Inquiry | |
| BADC-00854 | Mc-VC-PAB-SN38 | 1801838-28-7 |
| Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs). | Inquiry | |
| BADC-01396 | Exatecan | 171335-80-1 |
| Exatecan is an inhibitor of DNA topoisomerase I, with an IC50 of 2.2 μM (0.975 μg/mL). It can be used to study cancer. | Inquiry | |
| BADC-01405 | Exatecan hydrochloride | 144008-87-7 |
| Exatecan hydrochloride is the salt of Exatecan, which is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan is an inhibitor of DNA topoisomerase I. | Inquiry | |
| BADC-01479 | 7-MAD-MDCPT | 765871-81-6 |
| 7-MAD-MDCPT, a camptothecin analog, is the active moiety in an antibody drug conjugate (ADC). | Inquiry |
