Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-00606 | Deruxtecan | 1599440-13-7 |
| Deruxtecan analog is a drug-linker conjugate for antibody-drug conjugate (ADC). Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody-drug conjugate. DS-8201a significantly suppressed tumor growth in an immunocompetent mouse model with human HER2-expressing CT26.WT (CT26.WThHER2) cells. DS-8201a is currently in clinical trials. | Inquiry | |
| BADC-00015 | MC-Val-Ala-PBD | 1342820-51-2 |
| MC-Val-Ala-PBD is a protective group conjugated PBD, PBD bind in the minor groove of DNA. | Inquiry | |
| BADC-00633 | MC-Val-Cit-PAB-duocarmycin | 2055896-98-3 |
| MC-Val-Cit-PAB-duocarmycin is a drug-linker conjugate for ADC with potent antitumor activity by using duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB. | Inquiry | |
| BADC-00670 | Mal-PEG4-VA-PBD | 2259318-50-6 |
| Mal-PEG4-VA-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via Mal-PEG4-VA. | Inquiry | |
| BADC-00738 | MA-PEG4-VA-PBD | 1342820-68-1 |
| MA-PEG4-VA-PBD is a drug-linker conjugate for ADC by using PBD (Pyrrolobenzodiazepine dimers, a potent antitumor antibiotic), linked via MA-PEG4-VA. | Inquiry | |
| BADC-00851 | Tesirine | 1595275-62-9 |
| Tesirine (SG3249) is a drug-linker conjugates for ADC which is used in the treatment of several cancers. PBD Dimer is a DNA alkylating which inhibits DNA replication. | Inquiry | |
| BADC-00859 | DGN549-C | 2058075-34-4 |
| DGN549-C consists a cleavable ADC linker valine-alanine (va) and PBD dimer. DGN549 is a novel DNA-alkylating cytotoxic payload and can be used in the synthesis of antibody-drug conjugates (ADCs). | Inquiry | |
| BADC-00865 | Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA | 2259318-49-3 |
| Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is a drug-linker conjugate for ADC by using the antitumor antibiotic, Duocarmycin SA, linked via Mal-PEG4-VC-PAB-DMEA-Seco. | Inquiry | |
| BADC-00871 | Fmoc-Val-Cit-PAB-Duocarmycin TM | |
| Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate for ADC by using the antitumor antibiotic, Duocarmycin TM, linked via Fmoc-Val-Cit-PAB. | Inquiry |
