Songorine - CAS 509-24-0

Songorine - CAS 509-24-0 Catalog number: BADC-00073

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C20-diterpenoid alkaloid from plants of the Aconitum genus, Ranunculaceae. Adrenergic and Serotonergic stimulant; CNS stimulant; antiarrhythmic.

General Information

Category
ADCs Cytotoxin
Product Name
Songorine
CAS
509-24-0
Catalog Number
BADC-00073
Molecular Formula
C22H31NO3
Molecular Weight
357.49

Chemical Structure

  • Songorine

Ordering Information

Catalog Number Size Price Stock Quantity
BADC-00073 20mg $299 In stock
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Purity
98 % (NMR).
Appearance
Solid powder
Synonyms
(20R)-21-Ethyl-1α,15β-dihydroxy-4-methyl-16-methylene-7α,20-cycloveatchan-12-one;
Solubility
well in chloroform.
Storage
Store at +4 °C, in dark place.
Application
ADCs Cytotoxin
Quality Standard
Enterprise Standard
Shipping
Room temperature, or blue ice upon request.
Melting Point
201-203° C.
Density
1.29g/cm3
Quantity
Milligrams-Grams
1.Using cell membrane chromatography and HPLC-TOF/MS method for
Cao Y;Chen XF;Lü DY;Dong X;Zhang GQ;Chai YF J Pharm Anal. 2011 May;1(2):125-134. doi: 10.1016/S2095-1779(11)70022-3. Epub 2012 Jan 30.
An offline two-dimensional system combining a rat cardiac muscle cell membrane chromatography time-of-flight mass spectrometry (CMC-TOF/MS) with a high Performance liquid chromatography time-of-flight mass spectrometry (HPLC-TOF/MS) was established for investigating the parent components and metabolites in rat urine samples after administration of the roots of ;Aconitum carmichaeli.; On the basis ofthe analysis of the first dimension, retention components of the urine sample were collected into 30 fractions (one fraction per minute). Then offline analysis of the second dimension was carried out. 34 compounds including 24 parent alkaloids and 10 potential metabolites were identified from the dosed rat urine, and then binding affinities of different compounds on cell membranes were compared and influences of some functional groups on activity were estimated with the semi-quantification and curve fitting method. As a result, binding affinities decreased along with the process of deacylation, debenzoylation and demethylation, which may be related to the alleviation of toxicity in the procedure of herb processing or metabolism. Moreover, some minor components in rat urine (Songorine, 14-benzoylneoline, Deoxyaconitine, etc.
2.[Quality consistency evaluation of Fuzi formula granules using determination of multi-component contents by HPLC-MS/MS method].
Tang JF;Zhang SQ;Wang XY;Li WX;He YN;Cao ZX;Zhang DK Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1871-1879. doi: 10.19540/j.cnki.cjcmm.20180208.006.
To establish HPLC-MS/MS method for simultaneous determination of 14 toxic or active components in Fuzi formula granules, and further analyze the quality consistency of 29 batches of formula granules by considering the cluster analysis (CA), principal component analysis (PCA), and partial least squares discriminant analysis (PLS-DA) and other chemometrics methods. Phenomenonex Gemini C18 column (4.6 mm×150 mm, 5 μm) was used with 0.1% formic acid solution (A) -acetonitrile (B) as the mobile phase. The mass spectrum was scanned by ESI⁺ multiple reaction monitoring (MRM) mode. The contents of aconitine, mesaconitine, hypaconitine, Indaconitine, benzoylaconine, benzoylmesaconine, benzoylhypaconitine, aconine, fuziline, neoline, talatisamine, songorine, higenamine and salsoline were determined. The results showed that 14 compounds had a good linear relationship within their respective concentration range (R²>0.990 0). The limit of quantification was 2.07-7.71 mg·L⁻¹, and the average recovery was 96.07%-102.2%. The content determination results demonstrated that all batches of Fuzi formula granules had very low hypertoxic ingredients and high safety, while the content of active ingredients was greatly different.
3.Antiviral activity of aconite alkaloids from Aconitum carmichaelii Debx.
Xu W;Zhang M;Liu H;Wei K;He M;Li X;Hu D;Yang S;Zheng Y Nat Prod Res. 2017 Dec 22:1-5. doi: 10.1080/14786419.2017.1416385. [Epub ahead of print]
Four diterpenoid alkaloids, namely, (a) hypaconitine, (b) songorine, (c) mesaconitine and (d) aconitine, were isolated from the ethanol root extract of Aconitum carmichaelii Debx. The antiviral activities of these alkaloids against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) were evaluated. Antiviral activity test in vivo showed that compounds a and c, which were C19-diterpenoid alkaloids, showed inactivation efficacy values of 82.4 and 85.6% against TMV at 500 μg/mL, respectively. By contrast, compound c presented inactivation activity of 52.1% against CMV at 500 μg/mL, which was almost equal to that of the commercial Ningnanmycin (87.1% inactivation activity against TMV and 53.8% inactivation activity against CMV). C19-Diterpenoid alkaloids displayed moderate to high antiviral activity against TMV and CMV at 500 μg/mL, dosage plays an important role in antiviral activities. This paper is the first report on the evolution of aconite diterpenoid alkaloids for antiviral activity against CMV.

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Historical Records: Mc-Leu-Gly-Arg | AcLys-PABC-VC-Aur0101 | 4-Formyl-N-(2-(3-Methoxyphenoxy)ethyl)benzamide | Azido-PEG4-C2-acid | Songorine
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