Sandramycin - CAS 100940-65-6

Sandramycin - CAS 100940-65-6 Catalog number: BADC-00808

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity.

Category
ADCs Cytotoxin
Product Name
Sandramycin
CAS
100940-65-6
Catalog Number
BADC-00808
Molecular Formula
C60H76N12O16
Molecular Weight
1221.32
Target
DNA
Sandramycin

Ordering Information

Catalog Number Size Price Quantity
BADC-00808 -- $--
Inquiry
Description
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity.
Synonyms
(-)-Sandramycin; 3-Hydroxy-N-[23-[(3-hydroxyquinoline-2-carbonyl)amino]-8,11,28,31-tetramethyl-2,6,9,12,15,22,26,29,32,35-decaoxo-7,27-di(propan-2-yl)-5,25-dioxa-1,8,11,14,21,28,31,34-octazatricyclo[34.4.0.016,21]tetracontan-3-yl]quinoline-2-carboxamide
IUPAC Name
3-hydroxy-N-[23-[(3-hydroxyquinoline-2-carbonyl)amino]-8,11,28,31-tetramethyl-2,6,9,12,15,22,26,29,32,35-decaoxo-7,27-di(propan-2-yl)-5,25-dioxa-1,8,11,14,21,28,31,34-octazatricyclo[34.4.0.016,21]tetracontan-3-yl]quinoline-2-carboxamide
Canonical SMILES
CC(C)C1C(=O)OCC(C(=O)N2CCCCC2C(=O)NCC(=O)N(CC(=O)N(C(C(=O)OCC(C(=O)N3CCCCC3C(=O)NCC(=O)N(CC(=O)N1C)C)NC(=O)C4=NC5=CC=CC=C5C=C4O)C(C)C)C)C)NC(=O)C6=NC7=CC=CC=C7C=C6O
InChI
InChI=1S/C60H76N12O16/c1-33(2)51-59(85)87-31-39(65-55(81)49-43(73)25-35-17-9-11-19-37(35)63-49)57(83)71-23-15-13-21-41(71)53(79)62-28-46(76)68(6)30-48(78)70(8)52(34(3)4)60(86)88-32-40(66-56(82)50-44(74)26-36-18-10-12-20-38(36)64-50)58(84)72-24-16-14-22-42(72)54(80)61-27-45(75)67(5)29-47(77)69(51)7/h9-12,17-20,25-26,33-34,39-42,51-52,73-74H,13-16,21-24,27-32H2,1-8H3,(H,61,80)(H,62,79)(H,65,81)(H,66,82)
InChIKey
WXIVYIYCEBUEHL-UHFFFAOYSA-N
Density
1.42 g/cm3
Solubility
Soluble in ethanol, methanol, DMF or DMSO limited water solubility 10 mm in DMSO
Melting Point
208-212°C
Flash Point
872.1ºC
Index Of Refraction
1.659
LogP
1.13540
PSA
357.10000
Vapor Pressure
0mmHg at 25°C
In Vitro
Sandramycin has antimicrobial activity wtih MIC values of 0.024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Bacillus subtilis (Rec+) A22508-2, B. subtilis (Rec-) A22509-2-2, Staphylocccus aureus 209P-A9497, S. aureus (echinomycin-resistant) A9628, Streptococcus faecalis A96 1 1, Escherichia coli A151 19 and E. coli (actinomycin-sensitive) A21780 (AS-19), respectively. Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC50 values of 0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively.
In Vivo
Sandramycin (0.0125-1.6mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice. Animal Model: CDF1 female mice injected with leukemia P388 cells Dosage: 0.0125mg/kg, 0.025mg/kg, 0.05mg/kg, 0.1mg/kg, 0.2mg/kg, 0.4mg/kg, 0.8mg/kg, 1.6mg/kg Administration: Intraperitoneal injection; daily; for 5 days Result: Was moderately active in vivo against leukemia P388 in mice.
Source
Bacterium/Kribbella sp.
Appearance
Antibiotic, DNA intercalator & crosslinker
Purity
≥95%
Shelf Life
≥ 2 years
Shipping
Room temperature
Storage
-20 °C, protect from light.
Boiling Point
1518.4°C at 760 mmHg
Form
Solid

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: MC-DM1 | BA-3011 | DM3 | DM4 | N-Me-L-Ala-maytansinol | Sandramycin

Services

Products

Resource

Send Inquiry

Verification code
Inquiry Basket