Sandramycin - CAS 100940-65-6

Sandramycin - CAS 100940-65-6 Catalog number: BADC-00808

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Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity.

General Information

Category
ADCs Cytotoxin
Product Name
Sandramycin
CAS
100940-65-6
Catalog Number
BADC-00808
Molecular Formula
C60H76N12O16
Molecular Weight
1221.32 g/mol
Target
DNA

Chemical Structure

  • Sandramycin
Purity
≥95%
Appearance
Antibiotic, DNA intercalator & crosslinker
Synonyms
(-)-Sandramycin; 3-Hydroxy-N-[23-[(3-hydroxyquinoline-2-carbonyl)amino]-8,11,28,31-tetramethyl-2,6,9,12,15,22,26,29,32,35-decaoxo-7,27-di(propan-2-yl)-5,25-dioxa-1,8,11,14,21,28,31,34-octazatricyclo[34.4.0.016,21]tetracontan-3-yl]quinoline-2-carboxamide
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility. 10 mM in DMSO.
Storage
-20 °C, protect from light.
Shelf Life
≥ 2 years
Shipping
Room temperature
Boiling Point
1518.4°C at 760 mmHg
Melting Point
208-212°C
Density
1.42 g/cm3
Canonical SMILES
CC(C)C1C(=O)OCC(C(=O)N2CCCCC2C(=O)NCC(=O)N(CC(=O)N(C(C(=O)OCC(C(=O)N3CCCCC3C(=O)NCC(=O)N(CC(=O)N1C)C)NC(=O)C4=NC5=CC=CC=C5C=C4O)C(C)C)C)C)NC(=O)C6=NC7=CC=CC=C7C=C6O
InChI Key
WXIVYIYCEBUEHL-UHFFFAOYSA-N
InChI
InChI=1S/C60H76N12O16/c1-33(2)51-59(85)87-31-39(65-55(81)49-43(73)25-35-17-9-11-19-37(35)63-49)57(83)71-23-15-13-21-41(71)53(79)62-28-46(76)68(6)30-48(78)70(8)52(34(3)4)60(86)88-32-40(66-56(82)50-44(74)26-36-18-10-12-20-38(36)64-50)58(84)72-24-16-14-22-42(72)54(80)61-27-45(75)67(5)29-47(77)69(51)7/h9-12,17-20,25-26,33-34,39-42,51-52,73-74H,13-16,21-24,27-32H2,1-8H3,(H,61,80)(H,62,79)(H,65,81)(H,66,82)
Source
Bacterium/Kribbella sp.
Form
Solid

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