Description
Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
Propyne-PEG1-CH2CH2COOH; 3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid; 3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid; Propargyl-PEG1-COOH; Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-
IUPAC Name
3-(2-prop-2-ynoxyethoxy)propanoic acid
Canonical SMILES
C#CCOCCOCCC(=O)O
InChI
InChI=1S/C8H12O4/c1-2-4-11-6-7-12-5-3-8(9)10/h1H,3-7H2,(H,9,10)
InChIKey
NNWHATPXNWOQKD-UHFFFAOYSA-N
Solubility
Soluble in DMSO
Biological Activity
Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]
Appearance
Pale Yellow Oily Matter
Shelf Life
0-4℃ for short term (days to weeks), or -20℃ for long term (months).
Shipping
Room temperature, or blue ice upon request.
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Pictograms
Corrosive; Irritant
Boiling Point
306.6±27.0°C at 760 mmHg