Polyketomycin - CAS 200625-47-4

Polyketomycin - CAS 200625-47-4 Catalog number: BADC-00819

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities.

Category
ADCs Cytotoxin
Product Name
Polyketomycin
CAS
200625-47-4
Catalog Number
BADC-00819
Molecular Formula
C44H48O18
Molecular Weight
864.84
Polyketomycin

Ordering Information

Catalog Number Size Price Quantity
BADC-00819 -- $--
Inquiry
Description
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities.
Synonyms
1,3,7,10,12(2H,4H,5H)-Naphthacenepentone, 4a,12a-dihydro-4-((5-((2,6-dideoxy-4-O-(2-hydroxy-3,6-dimethylbenzoyl)-3-C-methylhexopyranosyl)oxy)tetrahydro-6-methyl-2H-pyran-2-yl)oxy)-2-(1-hydroxyethylidene)-8-methoxy-6-methyl-4a,11,12a-trihydroxy-
IUPAC Name
[(2S,3R,4R,6S)-6-[(2R,3S,6S)-6-[[(1S,4aS,12aR)-3-acetyl-4,4a,6,12a-tetrahydroxy-9-methoxy-11-methyl-2,5,7,10-tetraoxo-1,12-dihydrotetracen-1-yl]oxy]-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 2-hydroxy-3,6-dimethylbenzoate
Canonical SMILES
CC1C(CCC(O1)OC2C(=O)C(=C(C3(C2(CC4=C(C5=C(C(=O)C=C(C5=O)OC)C(=C4C3=O)O)C)O)O)O)C(=O)C)OC6CC(C(C(O6)C)OC(=O)C7=C(C=CC(=C7O)C)C)(C)O
InChI
InChI=1S/C44H48O18/c1-16-9-10-17(2)33(47)28(16)41(53)62-39-21(6)59-27(15-42(39,7)54)60-24-11-12-26(58-20(24)5)61-40-36(50)30(19(4)45)37(51)44(56)38(52)31-22(14-43(40,44)55)18(3)29-32(35(31)49)23(46)13-25(57-8)34(29)48/h9-10,13,20-21,24,26-27,39-40,47,49,51,54-56H,11-12,14-15H2,1-8H3/t20-,21+,24+,26+,27+,39-,40-,42-,43-,44-/m1/s1
InChIKey
IFCBPTPGDINHLK-VSYKUZCLSA-N
Density
1.5±0.1 g/cm3
Solubility
10 mm in DMSO
Melting Point
194-196°C (dec.)
LogP
2.52400
PSA
279.18000
In Vitro
Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively.
In Vivo
The acute toxicity (LD50, ip) of polyketomycin in mice is estimated to be 6.25-12.5mg/kg.
Appearance
Orange Powder
Purity
>98.0%
Shelf Life
-20℃ 3 years powder; -80℃ 2 years in solvent
Shipping
Room temperature
Storage
Store at -5°C,keep in dry and avoid sunlight.
Boiling Point
1032.6±65.0°C at 760 mmHg
Form
Solid

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Polyketomycin

Services

Products

Resource

Send Inquiry

Verification code
Inquiry Basket