Mensacarcin - CAS 808750-39-2

Mensacarcin - CAS 808750-39-2 Catalog number: BADC-00839

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Mensacarcin is a bacterial metabolite that has been found in S. bottropensis and has anticancer activity. It strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways.

Category
ADCs Cytotoxin
Product Name
Mensacarcin
CAS
808750-39-2
Catalog Number
BADC-00839
Molecular Formula
C21H24O9
Molecular Weight
420.41
Mensacarcin

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BADC-00839 -- $--
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Description
Mensacarcin is a bacterial metabolite that has been found in S. bottropensis and has anticancer activity. It strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways.
Synonyms
GNF-Pf-1439
IUPAC Name
(1S,9S,10S,11S,12S,13S,14R)-11,12,14-trihydroxy-7,9-dimethoxy-13-methyl-12-[(2R,3S)-3-methyloxirane-2-carbonyl]-15-oxatetracyclo[8.4.1.01,10.03,8]pentadeca-3(8),4,6-trien-2-one
Canonical SMILES
CC1C(C23C(=O)C4=C(C(C2(O3)C(C1(C(=O)C5C(O5)C)O)O)OC)C(=CC=C4)OC)O
InChI
InChI=1S/C21H24O9/c1-8-14(22)20-15(23)10-6-5-7-11(27-3)12(10)17(28-4)21(20,30-20)18(25)19(8,26)16(24)13-9(2)29-13/h5-9,13-14,17-18,22,25-26H,1-4H3/t8-,9-,13+,14+,17-,18-,19+,20+,21+/m0/s1
InChIKey
WWNXYRCJJRRWAQ-ALCXHWRFSA-N
Density
1.5±0.1 g/cm3
Solubility
10 mm in DMSO
Flash Point
232.9±25.0 °C
Index Of Refraction
1.647
LogP
5.48
Vapour Pressure
0.0±2.1 mmHg at 25°C
In Vitro
Mensacarcin (0-100 μM; 24 hours) exhibits general cytostatic but type-specific cytotoxic effects for melanoma cells. Mensacarcin (2-50 μM; 15 hours) induces rapid apoptotic cell death in melanoma cells. Mensacarcin exhibits potent cytostatic properties (mean of 50% growth inhibition=0.2 μM) in almost all cell lines of the National Cancer Institute (NCI)-60 cell line screen and relatively selective cytotoxicity against melanoma cells. Mensacarcin is a highly oxygenated polyketide that was first isolated from soil-dwelling Streptomyces bacteria. Mensacarcin impairs mitochondrial function in melanoma cells. Cell Viability Assay Cell Line: SK-Mel-28 and SK-Mel-5 melanoma cells, HCT-116 colon cancer cells Concentration: 0.01, 0.1, 1, 10, 100 μM Incubation Time: 24 hours Result: Induced concentration- and time-dependent cell death in the two tested melanoma cell lines. HCT-116 colon carcinoma cells were strongly inhibited. Western Blot Analysis Cell Line: SK-Mel-28, SK-Mel-5 cells Concentration: 2, 10, 50 μM Incubation Time: 15 hours Result: Induced the formation of 89-kDa PARP-1 fragments as well as caspase-3 activation in SK-Mel-28 and SK-Mel-5 beginning between 6 and 15 h after exposure.
Appearance
Solid Power
Purity
≥95%
Shelf Life
-20℃ 3 years powder; -80℃ 2 years in solvent
Shipping
Room temperature
Storage
Store at -20°C
Boiling Point
656.8±55.0 °C at 760 mmHg
Form
Solid

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: γ-Fagarine | SMCC | γ-Amanitin | Mensacarcin

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