Description
Hydroxy-PEG3-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
HO-PEG3-CH2CH2COOtBu; Hydroxy-PEG3-(CH2)2-Boc; OH-PEG3-TBA; OH-PEG3-CH2CH2COOtBu; HO-PEG3-t-butyl ester; tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate; 3-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester; 12-Hydroxy-4,7,10-trioxadodecanoic Acid tert-Butyl Ester; 2-Methyl-2-propanyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate; Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester; tert-Butyl triethylene glycol-O-propionate
IUPAC Name
tert-butyl 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanoate
Canonical SMILES
CC(C)(C)OC(=O)CCOCCOCCOCCO
InChI
InChI=1S/C13H26O6/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h14H,4-11H2,1-3H3
InChIKey
KSXVEOLRERRELV-UHFFFAOYSA-N
Density
1.052 g/mL at 20°C
Solubility
Soluble in DMSO (10 mm)
Vapor Pressure
7.78E-07mmHg at 25°C
Biological Activity
Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2- (CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Appearance
Colorless to light yellow to light orange clear liquid
Shipping
Room temperature, or blue ice upon request.
Boiling Point
365.8±27.0°C (Predicted)