Glucopiericidin A - CAS 108073-65-0

Glucopiericidin A - CAS 108073-65-0 Catalog number: BADC-00810

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Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts.

General Information

Category
ADCs Cytotoxin
Product Name
Glucopiericidin A
CAS
108073-65-0
Catalog Number
BADC-00810
Molecular Formula
C31H47NO9
Molecular Weight
577.71 g/mol
Target

Chemical Structure

  • Glucopiericidin A
Purity
≥95%
Appearance
Amorphous Powder
Synonyms
10'-O-beta-D-Glucopyranosylpiercidin A1; Antibiotic MT 1882-II; 2-[(2E,5E,7E)-10-[(2R,3R,4S,5S,6R,9R,10R)-2-[(E)-but-2-en-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]oxy-3-methyldeca-2,5,7-trienyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one
Solubility
10 mM in DMSO
Storage
-20°C
Shelf Life
0-4℃ for short term (days to weeks), or -20℃ for long term (months).
Shipping
Room temperature
Boiling Point
735.8 °C at 760 mmHg
Density
1.21 g/cm3
Canonical SMILES
CC=C(C)C(C(C)C=C(C)C=CCC(=CCC1=C(C(=O)C(=C(N1)OC)OC)C)C)OC2C(C(C(C(O2)CO)O)O)O
InChI Key
YQOARHMNLCWEPG-DFTUVXBYSA-N
InChI
InChI=1S/C31H47NO9/c1-9-19(4)28(41-31-27(37)26(36)25(35)23(16-33)40-31)20(5)15-18(3)12-10-11-17(2)13-14-22-21(6)24(34)29(38-7)30(32-22)39-8/h9-10,12-13,15,20,23,25-28,31,33,35-37H,11,14,16H2,1-8H3,(H,32,34)/b12-10+,17-13+,18-15+,19-9+/t20-,23-,25-,26+,27-,28+,31+/m1/s1

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Historical Records: Mc-Leu-Gly-Arg | AcLys-PABC-VC-Aur0101 | 4-Formyl-N-(2-(3-Methoxyphenoxy)ethyl)benzamide | Azido-PEG4-C2-acid | Songorine | Glucopiericidin A
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