1.Tetrahydroberberine, a pharmacologically active naturally occurring alkaloid.
Pingali S1, Donahue JP2, Payton-Stewart F1. Acta Crystallogr C Struct Chem. 2015 Apr;71(Pt 4):262-5. doi: 10.1107/S2053229615004076. Epub 2015 Mar 10.
Tetrahydroberberine (systematic name: 9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-benzo[g][1,3]benzodioxolo[5,6-a]quinolizine), C20H21NO4, a widely distributed naturally occurring alkaloid, has been crystallized as a racemic mixture about an inversion center. A bent conformation of the molecule is observed, with an angle of 24.72 (5)° between the arene rings at the two ends of the reduced quinolizinium core. The intermolecular hydrogen bonds that play an apparent role in crystal packing are 1,3-benzodioxole -CH2···OCH3 and -OCH3···OCH3 interactions between neighboring molecules.