Albendazole - CAS 54965-21-8

Albendazole - CAS 54965-21-8 Catalog number: BADC-00228

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Albendazole is an anthelmintic. It prevents the enzymatic process that causes the parasite to absorb glucose, leading to its death.

General Information

Category
ADCs Cytotoxin
Product Name
Albendazole
CAS
54965-21-8
Catalog Number
BADC-00228
Molecular Formula
C12H15N3O2S
Molecular Weight
265.33

Chemical Structure

  • Albendazole
Purity
98% by HPLC
Appearance
White to Off-white Solid
Synonyms
SKF-62979; SKF 62979; SKF62979; Eskazole; Zentel; Albenza; Valbazen
Solubility
Soluble in acetic acid, chloroform
Storage
Store at -20°C (dark)
Application
ADCs Cytotoxin
Quantity
Milligrams-Grams
Melting Point
193-198°C
Density
1.3±0.1 g/cm3
Canonical SMILES
CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC
InChI Key
HXHWSAZORRCQMX-UHFFFAOYSA-N
InChI
InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Source
Synthetic
1.Comparison of the Pharmacokinetics of Albendazole and its Major Metabolites after Oral Administration of Albendazole as a Suspension and as a Paste Formulation to Sheep
S. E. MARRINE, J. A. BOGAN, W. VANDAELE*. Zbl. Vet. Med. B, 28, 19-26 (1981)
Albendazole is a member of the benzimidazole group of anthelmintics with broad-spectrum activity against gastro-intestinal roundworms including inhibited larval stages, tapeworms, liver flukes and lungworms in many species. In the ruminant animal the rumen acts as a “reservoir” of undissolved albendazole and rhe slow passage of drug through the rumen serves to maintain concentrations of albendazole or active metabolic products in the more distal parts of the gastro-intestinal tract and in the systemic compartment over a number of days. Ruminal by-pass via the oesophageal (reticular) groove could lead to inferior activity of albendazole. In a previous report on albendazole pharmacokinetics we found little evidence of subsitantial ruminal by-pass with albendazole given orally as a drench (suspension) although small amounts passed (directly to the abomasum in individual sheep.

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