1.Comparison of the Pharmacokinetics of Albendazole and its Major Metabolites after Oral Administration of Albendazole as a Suspension and as a Paste Formulation to Sheep
S. E. MARRINE, J. A. BOGAN, W. VANDAELE*. Zbl. Vet. Med. B, 28, 19-26 (1981)
Albendazole is a member of the benzimidazole group of anthelmintics with broad-spectrum activity against gastro-intestinal roundworms including inhibited larval stages, tapeworms, liver flukes and lungworms in many species. In the ruminant animal the rumen acts as a “reservoir” of undissolved albendazole and rhe slow passage of drug through the rumen serves to maintain concentrations of albendazole or active metabolic products in the more distal parts of the gastro-intestinal tract and in the systemic compartment over a number of days. Ruminal by-pass via the oesophageal (reticular) groove could lead to inferior activity of albendazole. In a previous report on albendazole pharmacokinetics we found little evidence of subsitantial ruminal by-pass with albendazole given orally as a drench (suspension) although small amounts passed (directly to the abomasum in individual sheep.